705967-83-5

Usage

Uses

Used in Biochemistry and Pharmaceutical Research:
2-(6-Amino-9H-purin-9-yl)-1,5-anhydro-2-deoxy-4,6-O-[(R)-phenylmethylene]-D-altritol is used as a specialized reagent in the synthesis of certain nucleoside analogues. Its unique structure allows for the development of new compounds with potential therapeutic applications.
Used in the Treatment of Viral Infections:
2-(6-Amino-9H-purin-9-yl)-1,5-anhydro-2-deoxy-4,6-O-[(R)-phenylmethylene]-D-altritol is used as a potential therapeutic agent for the treatment of various diseases, particularly those related to viral infections. Its molecular stability and unique structure make it a promising candidate for the development of antiviral drugs.
Used in the Treatment of Cancer:
2-(6-Amino-9H-purin-9-yl)-1,5-anhydro-2-deoxy-4,6-O-[(R)-phenylmethylene]-D-altritol is also used as a potential therapeutic agent for the treatment of cancer. Its ability to target specific molecular pathways involved in cancer development and progression makes it a valuable tool in the development of new cancer treatments.

Upstream product

• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 
• 92283-88-0 1,5:2,3-dianhydro-4,6-O-benzylidene-D-allitol 
• 705967-79-9 2-(2-amino-6-chloropurin-9-yl)-1,5-anhydro-4,6-O-benzylidene-2-deoxy-D-altro-hexitol 
• 10310-21-1 2-Amino-6-chloropurin 

Downstream Products

• 705967-84-6 1,5-anhydro-4,6-O-benzylidene-2-(N²-iso-butyrylguanin-9-yl)-2-deoxy-D-altro-hexitol 
• 705967-85-7 1,5-anhydro-4,6-O-benzylidene-3-O-tert-butyldimethylsilyl-2-(N²-iso-butyrylguanin-9-yl)-2-deoxy-D-altro-hexitol 
• 937031-41-9 1,5-anhydro-4,6-O-benzylidene-2-[N²,O⁶-bis(9-fluorenylmethoxycarbonyl)guanin-9-yl]-2-deoxy-3-O-(9-fluorenylmethoxycarbonyl)-D-altro-hexitol 
• 937031-39-5 1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-[N²-(9-fluorenylmethoxycarbonyl)guanin-9-yl]-D-altro-hexitol 
• 937031-40-8 1,5-anhydro-4,6-O-benzylidene-2-[N²,O⁶-bis(9-fluorenylmethoxycarbonyl)guanin-9-yl]-2-deoxy-D-altro-hexitol 
• 937031-59-9 1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-[N²-(9-fluorenylmethoxycarbonyl)guanin-9-yl]-3-O-trimethylsilyl-D-altro-hexitol 
• 937031-60-2 1,5-anhydro-4,6-O-benzylidene-2-[N²,O⁶-bis(9-fluorenylmethoxycarbonyl)guanin-9-yl]-2-deoxy-3-O-trimethylsilyl-D-altro-hexitol 

Relevant academic research and scientific papers

Synthesis of D-Altritol Nucleosides with a 3′ -O-Tert-Butyldimethylsilyl Protecting Group

Four D-altritol nucleosides with a 3′-O-tert- butyldimethylsilyl protecting group are synthesized (base moieties are adenine, guanine, thymine and 5-methylcytosine). The nucleosides are obtained by ring opening reaction of 1,5:2,3-dianhydro-4,6-O-benzylid

Synthesis of protected D-altritol nucleosides as building blocks for oligonucleotide synthesis

D-Altritol nucleosides with an adenine and uracil base moiety were obtained by nucleophilic opening of the epoxide ring of 1,5:2,3-dianhydro- 4,6-O-benzylidene-D-allitol using the sodium salt of the above mentioned bases. The use of a 2-trimethylsilylethyl protecting group for the O6- function of the guanine base offers a useful compromise between stability and acceptable alkylation yields of the N9-position if the guanine base. The cytosine nucleoside was synthesized starting from the uracil congener. The 3'-hydroxyl function was protected with a benzoyl group.