70659-92-6Relevant academic research and scientific papers
Synthesis and antiplasmodial evaluation of 1H-1,2,3-triazole grafted 4-aminoquinoline-benzoxaborole hybrids and benzoxaborole analogues
Saini, Anu,Kumar, Sumit,Raj, Raghu,Chowdhary, Shefali,Gendrot, Mathieu,Mosnier, Joel,Fonta, Isabelle,Pradines, Bruno,Kumar, Vipan
, (2021/02/26)
A library of 1H-1,2,3-triazole-tethered 4-aminoquinoline-benzoxaborole hybrids as well as aryl substituted benzoxaborole analogues was synthesized and screened for their anti-plasmodial efficacy against both chloroquine-susceptibility 3D7 and chloroquine-
Anti-Markovnikov Hydroazidation of Alkenes by Visible-Light Photoredox Catalysis
Wang, Juan-Juan,Yu, Wei
supporting information, p. 3510 - 3514 (2019/02/19)
The anti-Markovnikov hydroazidation of alkenes has been accomplished under visible-light irradiation by using [Ir(dF(CF3)ppy)2(dtbbpy)]PF6 as the photocatalyst and trimethylsilyl azide as the azidating agent. The reactions were greatly facilitated by water, the beneficial effect of which can be attributed to its participation in the reaction as the hydrogen donor, as indicated by deuterium isotope experiments. The reactions proceed under solvent free conditions in the presence of water. 4-Dimethylaminopyridine also exhibited a beneficial effect on the reactions. The present method enabled hydroazidation of several types of unactivated alkenes with good yields and high regioselectivity.
NOVEL ANTIMICROBIAL COMPOUNDS
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Page/Page column 17, (2013/04/10)
A new class of biotin protein ligase (BPL) inhibitors that have antibacterial activity against multiple Staphylococcus aureus isolates, including clinically important methicillin-resistant S. aureus (MRSA) are disclosed that are non-toxic.
Sequential one-pot ruthenium-catalyzed azide-alkyne cycloaddition from primary alkyl halides and sodium azide
Johansson, Johan R.,Lincoln, Per,Norden, Bengt,Kann, Nina
experimental part, p. 2355 - 2359 (2011/05/13)
An experimentally simple sequential one-pot RuAAC reaction, affording 1,5-disubstituted 1H-1,2,3-triazoles in good to excellent yields starting from an alkyl halide, sodium azide, and an alkyne, is reported. The organic azide is formed in situ by treating the primary alkyl halide with sodium azide in DMA under microwave heating. Subsequent addition of [RuClCp*(PPh 3)2] and the alkyne yielded the desired cycloaddition product after further microwave irradiation.
