706780-18-9Relevant articles and documents
Efficient synthesis of N-benzyl-3-aminopyrrolidine-2,5-dione and N-benzyl-3-aminopyrrolidin-2-one
Vo-Hoang, Yen,Gasse, Cécile,Vidal, Michel,Garbay, Christiane,Galons, Hervé
, p. 3603 - 3605 (2004)
Reaction of N-tert-butyloxycarbonylasparagine (Boc-Asn) with 2equiv of benzyl bromide in presence of cesium carbonate led to N-benzyl-3-Boc-amino- pyrrolidin-2,5-dione 1a (N-benzyl-3-Boc-aminosuccinimide). Borane dimethylsulfide reduced 3-Boc-aminopyrrolidine-2,5-dione 1a into 3-Boc-aminopyrrolidin-2-one 2a. The same procedure could also be used to prepare derivatives 1 and 2 substituted on the aromatic ring.