151213-41-1

Basic information

• Product Name: 1H-Pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione, tetrahydro-6-(phenylmethyl)-, (4aS-cis)-
• Synonyms: cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane;(1S,6R)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane;cis-8-Benzyl-7,9-dioxo-2,8-diazabicyclo(4.3.0)nonan;6-benzylte-(4aS,7aRdes)-trahydro-1H-pyrrolo[3,4-b]pyridine-5,7(6H,7aH)-dione;(4aR,7aS)-6-benzyltetrahydro-1H-pyrrolo[3,4-b]pyridine-5,7(6H,7aH)-dione
• CAS NO: 151213-41-1
• Molecular Formula: C14H16N2O2
• Molecular Weight: 244.293
• Mol File: 151213-41-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 468.5±45.0 °C(Predicted)
• Density: 1.227±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione, tetrahydro-6-(phenylmethyl)-, (4aS-cis)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione, tetrahydro-6-(phenylmethyl)-, (4aS-cis)-(151213-41-1)
• EPA Substance Registry System: 1H-Pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione, tetrahydro-6-(phenylmethyl)-, (4aS-cis)-(151213-41-1)

Safety Data

• Hazardous Substances Data: 151213-41-1(Hazardous Substances Data)

Usage

Uses

(1S,6R)-8-Benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane is a useful reagent in the preparation of (S,?S)?-?2,?8-?diazabicyclo[4.3.0]?nonane; a moxifloxacin chiral intermediate.

Upstream product

• 89-00-9 Pyridine-2,3-dicarboxylic acid 
• 18184-75-3 6-benzyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 
• 151434-04-7 (4aR,7aS)-6-benzyltetrahydro-1H-pyrrolo[3,4-b]pyridine-5,7(6H,7aH)-dione mono D-(-)-tartarate 
• 16308-68-2 allyl phenyl carbonate 
• 706780-18-9 N-benzyl-3-Boc-aminopyrrolidin-2,5-dione 
• 7760-07-8 D-gluconic acid 
• 1076198-93-0 6-benzyl-3,4-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 100-46-9 benzylamine 

Downstream Products

• 151213-40-0 (1S,6S)-2,8-diazabicyclo[4.3.0]nonane 
• 151213-39-7 (S,S)-8-benzyl-2,8-diazabicyclo[4.3.0]nonane-D-tartrate 

Relevant articles and documents

Convenient enzymatic resolution of cis-6-benzyltetrahydro-1H-pyrrolo[3,4-b]pyridine-5,7(6H,7aH)-dione using lipase to prepare the intermediate of moxifloxacin

A convenient and efficient route has been successfully developed for preparing (4aR,7aS)-6-benzyltetrahydro-1H-pyrrolo[3,4-b]pyridine-5,7(6H,7aH)-dione through enzyme-mediated kinetic resolution processes under mild and environmentally acceptable conditio

Preparation method of moxifloxacin intermediate

The invention discloses a preparation method of a moxifloxacin intermediate. The invention provides a preparation method of a compound as shown in a formula III, which comprises the following step: ina solvent, in the presence of alkali, carrying out cyclization reaction as shown in the specification on a compound as shown in a formula II to obtain the compound as shown in the formula III. The method is simple to operate, high in chiral selectivity, simple in process, high in yield and high in purity.

Preparation method of moxifloxacin side chain intermediate with rhodium catalysis

The invention discloses a preparation method of a moxifloxacin side chain intermediate with rhodium catalysis. The method includes steps of: under effect of a chiral catalyst, performing an asymmetrichydrogenation reaction to 6-benzyl-1,2,3,4-tetrahydro-p