70680-93-2

Usage

Uses

Used in Organic Synthesis:
3-Chloro-L-tyrosine is used as a building block for the creation of new pharmaceutical compounds and other chemical reactions, contributing to the advancement of medicinal chemistry.
Used in Pharmaceutical Industry:
3-Chloro-L-tyrosine is used as a precursor for the synthesis of specific drugs, highlighting its importance in the development of novel therapeutic agents.
Used in Anti-Cancer Research:
3-Chloro-L-tyrosine is studied for its potential therapeutic applications, particularly in the development of new anti-cancer agents, showcasing its promise in cancer treatment and research.

Upstream product

• 108-43-0 3-monochlorophenol 
• 113-24-6 sodium pyruvate 

Downstream Products

• 132574-58-4 α-D-L-2-chlorotyrosine 

Relevant academic research and scientific papers

Vinylation of Unprotected Phenols Using a Biocatalytic System

Readily available substituted phenols were coupled with pyruvate in buffer solution under atmospheric conditions to afford the corresponding para-vinylphenol derivatives while releasing only one molecule of CO2 and water as the by-products. This transformation was achieved by designing a biocatalytic system that combines three biocatalytic steps, namely the C-C coupling of phenol and pyruvate in the presence of ammonia, which leads to the corresponding tyrosine derivative, followed by deamination and decarboxylation. The biocatalytic transformation proceeded with high regioselectivity and afforded exclusively the desired para products. This method thus represents an environmentally friendly approach for the direct vinylation of readily available 2-, 3-, or 2,3-disubstituted phenols on preparative scale (0.5 mmol) that provides vinylphenols in high yields (65-83%).