70682-09-6Relevant articles and documents
Method for synthesizing 2-hylogen-3-alkyl substituted sulfonyl pyridine and midbody thereof in ultrasonic method
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Paragraph 0077; 0078; 0079; 0080; 0081, (2017/07/19)
The invention discloses a method for synthesizing 2-hylogen-3-alkyl substituted sulfonyl pyridine and midbody thereof in an ultrasonic method. The method comprises the following steps: enabling substituted amino acraldehyde, a catalyst and substituted cyanoethyl sulfone to react under ultrasonic until the complete reaction to prepare a reaction solution of a 2-hylogen-3-alkyl substituted sulfonyl pyridine midbody; adding halogen hydride into the reaction solution at a certain of temperature, facilitating the continuous reaction until the complete reaction, adding an alkaline solution into the reaction solution, adjusting a pH value to 7 to 8, standing, layering into a water layer and an organic layer, extracting the water layer by using an organic solvent, combining the organic layer, refining to obtain the 2-hylogen-3-alkyl substituted sulfonyl pyridine. The 2-hylogen-3-alkyl substituted sulfonyl pyridine is synthesized by adopting the ultrasonic method, so that the organic synthetic reaction can be effectively facilitated, the reaction speed is increased, the reaction yield is increased, and the environmental protection is facilitated; and the reaction time is short, the operation is simple, the reaction can be completed generally in two hours, the product yield is high, the quality is good, and the yield can reach 90 percent or more which is higher than the yield of the traditional solvent-method heating refluxing method.
Method for synthesizing 2-halo-3-substited alkylsulfonyl pyridine and intermediate compound thereof through microwave method
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Paragraph 0018; 0090; 0091; 0092; 0093; 0094; 0095, (2017/07/15)
The invention discloses a method for synthesizing 2-halo-3-substited alkylsulfonyl pyridine and an intermediate compound thereof through a microwave method. The method comprises the following steps: adding substituted amino acraldehyde, a catalyst and substituent cyanoethyl sulfone into a reactor, reacting under microwave radiation, and tracking the reaction until the substituted amino acraldehyde or the substituent cyanoethyl sulfone reacts completely, thereby preparing the intermediate compound; adding halogen hydride into the reaction solution, further reacting, and tracking detection until the reaction is complete; and adding an alkaline solution into the reaction solution to regulate the pH value to 7-8, standing for stratification to obtain a water layer and an organic layer, extracting the water layer with organic solvent, then merging the organic layers, and refining to prepare the 2-halo-3-substited alkylsulfonyl pyridine. According to the invention, the method for synthesizing 2-halo-3-substited alkylsulfonyl pyridine has the advantages of greenness, environment friendliness, short reaction time, simple operation process and high product yield; and the product has favorable bactericidal activity.
A water phase synthesis of 2 - halo - 3 - substituted hydrocarbyl sulfonyl pyridine and its intermediate method (by machine translation)
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Paragraph 0069; 0070, (2017/07/19)
The invention discloses a technique of synthesizing 2 - halo - 3 - substituted hydrocarbyl sulfonyl pyridine and intermediate method, substituted amino acrolein, catalyst and replace the cyanide sulfatoethyl, reaction at certain temperature, the tracking reaction to substituted amino acrolein or substituted cyanide b sulfone disappear, make the 2 - halo - 3 - substituted hydrocarbyl sulfonyl pyridine intermediates of the reaction solution; then adding hydrogen to the reaction solution to continue the reaction, tracking detection to the reaction is complete, to the reaction solution to adjust the pH value of the addition of alkali to the 7 - 8, to obtain the layered layer and the organic layer, the aqueous layer extracted by an organic solvent, then the combined organic layer, through the refining, make the 2 - halo - 3 - substituted hydrocarbyl sulfonyl pyridine. The aqueous synthesis of 2 - halo - 3 - substituted hydrocarbyl sulfonyl pyridine, effectively reduce the use of an organic solvent, in favor of environmental protection; short reaction time and the operation is simple, usually 4h can be completed within a reaction, the product yield is high, the yield can be 90% or more, higher than the traditional solvent the yield of heating reflux. (by machine translation)
