65753-48-2

Upstream product

• 2402-77-9 2,3-dichloro-pyridine 
• 5188-07-8 sodium thiomethoxide 
• 75-15-0 carbon disulfide 
• 85060-32-8 3-methylsulfanyl-pyridine N-oxide 
• 70682-09-6 2-chloro-3-methylsulphonyl-pyridine 
• 74-88-4 methyl iodide 
• 52200-48-3 3-bromo-2-chloropyridine 
• 624-92-0 Dimethyldisulphide 
• 109-09-1 2-chloropyridine 
• 18794-33-7 3-methylsulfanylpyridine 
• 695-37-4 3-fluoropyridine-1-oxide 
• 1851-22-5 3-chloropyridine-N-oxide 
• 6298-19-7 2-chloro-3-aminopyridine 

Downstream Products

• 70682-09-6 2-chloro-3-methylsulphonyl-pyridine 
• 65753-50-6 2-(3-tert-butylamino-2-hydroxypropoxy)-3-methylthiopyridine hydrogen maleate 

Relevant academic research and scientific papers

PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

One-pot double functionalisation of π-deficient heterocyclic lithium reagents

Herein, we report an efficient method for the double functionalisation of lithiated halogenopyridines, -pyrazines or -furopyridines through a convenient one-pot electrophilic trapping/nucleophilic substitution sequence.

New efficient access to thieno[3,2-b]pyridine derivatives via regioselective lithiation of 3-methylthiopyridine

The synthesis of thieno[3,2-b]pyridines was achieved using a three-step process allowing the construction of the thiophenic ring with 17-34% overall yields. The key step was the regioselective lithiation-bromination of the 3-methylthiopyridine induced by

HETEROARYLSULFONYL STILBENES AS 5-HT2A ANTAGONISTS

Compounds of formula I: are potent and selective antagonists of the 5-HT2A receptor, and hence are useful in treatment of various 10 CNS disorders.

TMSCH2Li-LiDMAE: a new nonnucleophilic reagent for C-2 lithiation of halopyridines

A new superbasic reagent has been discovered by combining TMSCH2Li and LiDMAE in hexane. This reagent was found highly efficient for the C-2 lithiation of sensitive chloro- and fluoropyridines. The metallation occurred chemo- and regioselectively at 0 °C avoiding the nucleophilic addition or substrate degradation commonly obtained with other alkyllithiums even at lower temperatures.

Unusual t-BuLi induced ortholithiation versus halogen-lithium exchange in bromopyridines: Two alternative strategies for functionalization

The reaction of lithiating agents with various 3-bromopyridines has been investigated. An unprecedented selectivity was observed with t-BuLi, which effected a clean lithiation at C-4. With 3-bromo and 2-chloro-3-bromo pyridines, the ortholithiation-exchange ratio was strongly electrophile and addition order dependent while 2-chloro-5-bromopyridine always gave exclusive C-4 substitution.

The Reaction of Some Halogenated Pyridine Thioethers and Sulphones with Carbon Disulphide

Dithiocarboxylation of some halogenated pyridine sulphones with carbon disulphide and sodium hydride leads to the formation of thiomethyl derivatives via Smiles rearrangement of the initially produced dianion, fragmentation and subsequent methylation.In one instance the pyridino-1,4-dithiine 7 was obtained.The thioether 2d was also converted into a thiomethyl derivative when subjected to the same reaction sequence.

Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines

Novel substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their pharmaceutically acceptable salts and their preparation are disclosed. These pyridines have pharmaceutical properties such as anti-hypertensive activity of rapid onset.