70738-04-4

Upstream product

• 71255-06-6 2-iodo-3,6-dimethoxybenzyl alcohol 
• 71255-03-3 2,5-dimethoxybenzyl vinyl ether 
• 71255-05-5 2-iodo-3,6-dimethoxybenzyl vinyl ether 
• 141058-36-8 2-(2',5'-dimethoxyphenyl)-1,3-dioxane 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 33524-31-1 2,5-dimethoxybenzyl alcohol 

Downstream Products

• 63160-44-1 2-hydroxymethyl-3-(3-methylbut-3-en-1-ynyl)benzene-1,4-diol 
• 63160-46-3 2,5-dihydroxy-6-(3-methylbut-3-en-1-ynyl)benzaldehyde 
• 73151-59-4 (7E,9E,11E)-aurocitrin 
• 81477-62-5 2-iodo-3-<(tert-butyldimethylsilyl)oxy>-6-hydroxybenzaldehyde 
• 81477-64-7 3-O-(tert-butyldimethylsilyl)frustulosin 
• 81477-61-4 2-iodo-3,6-bis<(tert-butyldimethylsilyl)oxy>benzaldehyde 
• 81477-68-1 2-iodo-3,6-bis<(tert-butyldimethylsilyl)oxy>cinnamaldehyde 
• 81477-63-6 bis(tert-butyldimethylsilyl)frustulosin 
• 81477-70-5 5-<2-iodo-3,6-bis(tert-butyldimethylsiloxy)phenyl>-2,4-pentadienal 
• 81477-65-8 1-<2-iodo-3,6-bis(tert-butyldimethylsiloxy)phenyl>-1,3,5-undecatriene 
• 81477-71-6 1-<2-iodo-3,6-bis(tert-butyldimethylsiloxy)phenyl>-1,3-undecadien-5-ol 

Relevant academic research and scientific papers

Ruthenium(0)-Catalyzed [4+2] Cycloaddition of Acetylenic Aldehydes with α-Ketols: Convergent Construction of Angucycline Ring Systems

Ruthenium(0) complexes modified by CyJohnPhos or RuPhos catalyze the successive C-C coupling of acetylenic aldehydes with α-ketols to form [4+2] cycloadducts as single diastereomers. This method enables convergent construction of type€...II polyketide ring systems of the angucycline class. Ringing with efficiency: Ruthenium(0) complexes modified by either CyJohnPhos or RuPhos catalyze the successive C-C coupling of acetylenic aldehydes with α-ketols to form [4+2] cycloadducts as single diastereomers. This method enables convergent construction of type€...II polyketide ring systems of the angucycline class.

Total Synthesis of Methyl 1,5,8-Trimethoxy-1 H -isochromene-3-carboxylate and Its Derivatives via Palladium-Catalyzed Annulation of 2-Alkynylbenzaldehydes

A 7-step total synthesis of methyl 1,5,8-trimethoxy-1 H -isochromene-3-carboxylate and a 5-step synthesis of its C-3 derivatives are reported. Sonogashira coupling of 2-halobenzaldehydes with terminal acetylenes was employed to access 2-alkynylbenzaldehydes, which underwent a Pd-catalyzed annulation to afford the corresponding isochromene-containing products.

Total Synthesis of Frustulosin and Aurocitrin

The regioselective total syntheses of the novel fungal antibiotics frustulosin (1) and aurocitrin (2) were accomplished from 3,6-dihydroxy-2-iodobenzaldehyde (10) which was prepared by a regiodirected metalation of 2,5-dimethylbenzyl vinyl ether to establish the 1,2,3,4-tetrasubstitution pattern of these compounds.The unsaturated side chains of these hydroquinone antibiotics were attached by using the iodo aldehyde functionalities.The structures of these antibiotics are confirmed by synthesis.