70768-98-8

Basic information

• Product Name: 6-chloro-3,4-di-p-tolylpyridazine
• Synonyms: 6-chloro-3,4-di-p-tolylpyridazine
• CAS NO: 70768-98-8
• Molecular Weight: 294.783
• Mol File: 70768-98-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-chloro-3,4-di-p-tolylpyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-3,4-di-p-tolylpyridazine(70768-98-8)
• EPA Substance Registry System: 6-chloro-3,4-di-p-tolylpyridazine(70768-98-8)

Safety Data

• Hazardous Substances Data: 70768-98-8(Hazardous Substances Data)

Upstream product

• 70769-38-9 5,6-di-p-tolylpyridazin-3(2H)-one 
• 51490-06-3 1,2-di-p-tolyl-ethanone 
• 622-47-9 4-tolylacetic acid 
• 35675-44-6 4-methylphenylacetyl chloride 
• 108-88-3 toluene 

Relevant articles and documents

Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB1 receptor ligand antagonists

A series of sulfenamide and sulfonamide derivatives was synthesized and evaluated for the affinity at CB1 and CB2 receptors. The N-bornyl-S-(5,6-di-p-tolylpyridazin-3-yl)-sulfenamide, compound 11, displayed good affinity and high selectivity for CB1 receptors (Ki values of 44.6 nM for CB1 receptors and >40 μM for CB2 receptors, respectively). The N-isopinocampheyl-sulfenamide 12 and its sulfonamide analogue 22 showed similar selectivity for CB1 receptors with Ki values of 75.5 and 73.2 nM, respectively. These novel compounds behave as antagonists/inverse agonists at CB1 receptor in the [35S]-GTPγS binding assays, and none showed adequate predictive blood–brain barrier permeation, exhibiting low estimated LD50. However, testing compound 12 in a supraspinal analgesic test (hot-plate) revealed that it was as effective as the classic CB1 receptor antagonist rimonabant, in reversing the analgesic effect of a cannabinoid agonist.