708228-53-9Relevant academic research and scientific papers
A substituted 1,2-diarylethane from Cymbidium giganteum
Juneja,Sharma,Tandon
, p. 321 - 324 (1985)
In addition to sitosterol and taraxerone, a new substituted 1,2-diarylethane, gigantol has been isolated from Cymbidium giganteum and characterized as 1-(3′-hydroxy-5′-methoxyphenyl-2-(4″-hydroxy-5″-methoxyphenyl)ethane on the basis of physicochemical dat
Synthesis of?stilbene derivatives with inhibition of?SARS coronavirus replication
Li, Yue-Qing,Li, Ze-Lin,Zhao, Wei-Jie,Wen, Rui-Xing,Meng, Qing-Wei,Zeng, Yi
, p. 1084 - 1089 (2007/10/03)
Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 ( ≤ 0.5?mg?ml-1) and no significant cytotoxic effects were observed in vitro.
Styrylheterocycles as a novel class inhibitor of cyclooxygenase-2-mediated prostaglandin E2 production
Lee, Sang Kook,Park, Eun-Jung,Lee, Eunjung,Min, Hye-Young,Kim, Eun-Young,Lee, Taeho,Kim, Sanghee
, p. 2105 - 2108 (2007/10/03)
The inhibitory effects of a series of styrylheterocycles on the production of cyclooxygenase-2-mediated prostaglandin E2 (PGE2) were evaluated in lipopolysaccharide-stimulated RAW264.7 murine macrophages. A new series of potential inhibitors, including 3-[2-(4-methoxy-phenyl)-vinyl]- thiophene, have been identified, thus providing novel chemical leads for the further development of potential inhibitors in this capacity. The suppression of COX-2 mRNA expression by the active styrylheterocycles, in part, was involved in the inhibitory activity against the overproduction of PGE2.
