708262-58-2

Basic information

• Product Name: 2-bromo-N-(2-hydroxyphenyl)acetamide
• Synonyms: 2-bromo-N-(2-hydroxyphenyl)acetamide
• CAS NO: 708262-58-2
• Molecular Weight: 230.061
• Mol File: 708262-58-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-bromo-N-(2-hydroxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-(2-hydroxyphenyl)acetamide(708262-58-2)
• EPA Substance Registry System: 2-bromo-N-(2-hydroxyphenyl)acetamide(708262-58-2)

Safety Data

• Hazardous Substances Data: 708262-58-2(Hazardous Substances Data)

Upstream product

• 22118-09-8 2-bromoacetyl chloride 
• 95-55-6 2-amino-phenol 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 905509-75-3 2-[{5-(4-nitrophenyl)-1,3,4-oxadiazole-2-yl}sulphanyl]-N-(2-hydroxyphenyl)acetamide 
• 26673-71-2 ethyl 2-(3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)acetate 
• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 

Relevant articles and documents

INHIBITORS OF α-AMINO-β-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE

The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.

N-substituted derivatives of 5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl-2- sulfanyl acetamide as valuable bioactive compounds

In the described research work, a new series of N-substituted derivatives of 5-(4- chlorophenyl)-1,3,4-Oxadiazol-2-yl-2-sulfanyl acetamide has been synthesized. The synthesis was carried out by converting 4-chlorobenzoic acid (1) into ethyl 4-chlorobenzoate (2), 4- chlorobenzohydrazide (3) and then 5-(4-chlorophenyl)-1,3,4-Oxadiazol-2-thiol (4) respectively. The target molecules 6a-o were synthesized by reacting compound 4 with different N-alkyl/aryl substituted 2-bromoacetamide (5a-o) in equimolar ratios of using DMF and sodium hydride (NaH). The structure of all the synthesized compounds was confirmed by spectral data like EI-MS, IR and 1H-NMR. The compounds were also analysed for antimicrobial & hemolytic activity and most of them were found active against the selected microbial species at variable extent relative to reference standards. But 6f and 6o were the active against the selected panel of microbes and former was most potent one. This series revealed less toxicity and may consider for further biological screening and application trial except 6g and 6j, exhibiting high cytotoxicity.

Synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives potassium channel openers

As part of a search for new potassium channel openers, the synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives derived from transformation of the benzopyran skeleton of cromakalim were described. Several new 1,4-benzoxazine derivatives were provided with significant vasorelaxant activity with an overall pharmacological behavior similar to CRK (1f, 1i, 2d, 2e, 2f and 2i).