905509-75-3

Upstream product

• 62-23-7 4-nitro-benzoic acid 
• 99-77-4 ethyl 4-nitrobenzoate 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 23766-30-5 5-(p-nitrophenyl)-2-mercapto-1,3,4-oxadiazole 
• 708262-58-2 2-bromo-N-(2-hydroxyphenyl)acetamide 

Relevant academic research and scientific papers

Synthesis, characterization and pharmacological evaluation of n-substituted derivatives of 5-(4-nitrophenyl)-1,3,4-oxadiazole-2yl-2-sulphanyl acetamide

A series of new N-substituted 5-(4-nitrophenyl)-1,3,4-oxadiazole-2-yl-2- sulphanyl acetamides was synthesized and enzyme inhibiting activity was screened for all these chemical entities. Structural characterization of all these compounds was made by IR, EI-MS and 1H NMR. All derivatives demonstrated different extent of activity for lipoxygenase (LOX), acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Compounds 6j exhibited excellent lipoxygenase inhibitory potential but against acetylcholinesterase the inhibitory potential is not appreciable and it is inactive against butyrylcholinesterase. Similarly compound 6e have good inhibitory potential against lipoxygenase with IC50 value 50.41 ± 0.12 ?M while for acetylcholinesterase IC50 value is 174.21 ± 0.11 ?M and 6e does not show any inhibitory potential for butyrylcholinesterase. Compound 6o showed good inhibition against acetylcholinesterase and butyrylcholinesterase but for lipoxygenase its inhibitory activity is the least.