708271-54-9Relevant academic research and scientific papers
Synthesis of optically active 1,2,3-trisubstituted azetidines employing an organocatalytic approach with L-proline
Amongero, Marcela,Kaufman, Teodoro S.
, p. 1924 - 1927 (2013/04/10)
A concise organocatalytic approach towards optically active 1,2,3-trisubstituted azetidines, including a study of the scope and limitations of the synthetic sequence, is reported. The synthesis comprises the one-pot L-proline promoted three-component reac
Enantioselective mannich reactions with the practical proline mimetic N-(p-dodecylphenylsulfonyl)-2-pyrrolidinecarboxamide
Yang, Hua,Carter, Rich G.
supporting information; experimental part, p. 2246 - 2249 (2009/08/07)
A highly enantioselective and diastereoselective protocol for performing Mannich reactions has been developed by using a p-dodecylphenylsulfonamide-based proline catalyst. This catalyst facilitates the use of common, nonpolar solvents and increased concen
One-pot organocatalytic direct asymmetric synthesis of γ-amino alcohol derivatives
Córdova, Armando
, p. 1651 - 1654 (2007/10/03)
This report describes the unprecedented use of unmodified aldehydes as donors in catalytic three component one-pot asymmetric Mannich reactions. The Mannich-type reactions were also readily performed for the first time with both in situ generated and pref
The direct and enantioselective, one-pot, three-component, cross-Mannich reaction of aldehydes
Hayashi, Yujiro,Tsuboi, Wataru,Ashimine, Itaru,Urushima, Tatsuya,Shoji, Mitsuru,Sakai, Ken
, p. 3677 - 3680 (2007/10/03)
A double-crossed reaction: The use of proline as an organocatalyst enables a one-pot, direct, cross-Mannich reaction to be performed between two different aldehydes and 4-methoxyaniline in a highly syn-diastereo- and enantioselective manner (see scheme).
