605683-33-8

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 104-94-9 4-methoxy-aniline 
• 123-38-6 propionaldehyde 
• 5455-87-8 4-methoxy-N-(4-nitrobenzylidene)aniline 
• 39963-93-4 (E)-4-methoxy-N-(4-nitrobenzylidene)aniline 
• 708271-54-9 (2S,3S)-3-(4-Methoxy-phenylamino)-2-methyl-3-(4-nitro-phenyl)-propionaldehyde 

Downstream Products

• 916656-65-0 (2S,3S)-3-((4-methoxyphenyl)(methyl)amino)-2-methyl-3-(4-nitrophenyl)propan-1-ol 
• 1259379-92-4 C₁₇H₁₈N₂O₃ 

Relevant academic research and scientific papers

The Direct Organocatalytic Asymmetric Mannich Reaction: Unmodified Aldehydes as Nucleophiles

The unprecedented application of unmodified aldehydes as nucleophilic donors in direct catalytic asymmetric Mannich-type reactions is disclosed in a full account. Our efforts in broadening the applicability of chiral pyrrolidine-based catalysts in direct

Synthesis of optically active 1,2,3-trisubstituted azetidines employing an organocatalytic approach with L-proline

A concise organocatalytic approach towards optically active 1,2,3-trisubstituted azetidines, including a study of the scope and limitations of the synthetic sequence, is reported. The synthesis comprises the one-pot L-proline promoted three-component reac

Enantioselective mannich reactions with the practical proline mimetic N-(p-dodecylphenylsulfonyl)-2-pyrrolidinecarboxamide

A highly enantioselective and diastereoselective protocol for performing Mannich reactions has been developed by using a p-dodecylphenylsulfonamide-based proline catalyst. This catalyst facilitates the use of common, nonpolar solvents and increased concen

The Direct Catalytic Asymmetric Cross-Mannich Reaction: A Highly Enantioselective Route to 3-Amino Alcohols and α-Amino Acid Derivatives

The first proline-catalyzed direct catalytic asymmetric one-pot, three-component cross-Mannich reaction has been developed. The highly chemoselective reactions between two different unmodified aldehydes and one aromatic amine are new routes to 3-amino ald

One-pot organocatalytic direct asymmetric synthesis of γ-amino alcohol derivatives

This report describes the unprecedented use of unmodified aldehydes as donors in catalytic three component one-pot asymmetric Mannich reactions. The Mannich-type reactions were also readily performed for the first time with both in situ generated and pref

The direct and enantioselective, one-pot, three-component, cross-Mannich reaction of aldehydes

A double-crossed reaction: The use of proline as an organocatalyst enables a one-pot, direct, cross-Mannich reaction to be performed between two different aldehydes and 4-methoxyaniline in a highly syn-diastereo- and enantioselective manner (see scheme).