709007-52-3Relevant academic research and scientific papers
Use of a modified Leimgruber-Batcho reaction to prepare 6-chloro-5-fluoroindole
Bentley, Jon M.,Davidson, James E.,Duncton, Matthew A. J.,Giles, Paul R.,Pratt, Robert M.
, p. 2295 - 2300 (2007/10/03)
An efficient synthesis of the title indole, the heterocyclic core of the standard 5-HT2C receptor agonist Ro 60-0175, via a modified Leimgruber-Batcho indole synthesis is presented. The process can be used to make > 100 g quantities of the targ
Indoline derivatives as 5-HT2C receptor agonists
Bentley,Adams,Bebbington,Benwell,Bickerdike,Davidson,Dawson,Dourish,Duncton,Gaur,George,Giles,Hamlyn,Kennett,Knight,Malcolm,Mansell,Misra,Monck,Pratt,Quirk,Roffey,Vickers,Cliffe
, p. 2367 - 2370 (2007/10/03)
A series of 1-(1-indolinyl)-2-propylamines was synthesised and evaluated as 5-HT2C receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand
