118664-99-6

Usage

Uses

Used in Pharmaceutical Synthesis:
Benzene, 1-chloro-2-fluoro-4-methyl-5-nitro-, is used as a key intermediate in the synthesis of pharmaceuticals. Its presence in the molecular structure allows for the development of new drugs with specific therapeutic properties. Benzene, 1-chloro-2-fluoro-4-methyl-5-nitro-'s functional groups enable targeted modifications, leading to the creation of novel pharmaceutical agents.
Used in Agrochemical Production:
Benzene, 1-chloro-2-fluoro-4-methyl-5-nitroalso finds application in the production of agrochemicals, where it serves as a crucial intermediate. Its unique structure contributes to the development of effective pesticides and other agricultural chemicals, enhancing crop protection and yield.
Used in Organic Synthesis:
Benzene, 1-chloro-2-fluoro-4-methyl-5-nitro-, is utilized as an intermediate in organic synthesis, allowing for the creation of a wide range of organic compounds. Its versatile functional groups facilitate various chemical reactions, leading to the synthesis of complex organic molecules for different applications.
Used in Specialty Chemicals Production:
As a starting material, Benzene, 1-chloro-2-fluoro-4-methyl-5-nitro-, is employed in the production of specialty chemicals. Its unique properties make it suitable for the development of high-value chemical products used in various industries, such as coatings, adhesives, and polymers.
Safety Precautions:
Due to the potential hazards associated with Benzene, 1-chloro-2-fluoro-4-methyl-5-nitro-, including its toxicity and environmental impact, it is essential to follow safety precautions when handling and using this chemical. Proper protective equipment, waste disposal methods, and handling procedures should be strictly adhered to, ensuring the safety of both individuals and the environment.

Upstream product

• 259860-00-9 2-fluoro-4-methyl-5-nitro-phenylamine 
• 7494-45-3 1,2-dichloro-4-methyl-5-nitrobenzene 
• 5527-94-6 1-chloro-2-fluoro-4-methylbenzene 
• 452-80-2 2-fluoro-4-methylaniline 

Downstream Products

• 709007-52-3 [2-(4-chloro-5-fluoro-2-nitrophenyl)vinyl]dimethylamine 
• 1192181-56-8 C₁₀H₁₀ClFN₂O₂ 
• 63762-71-0 2-chloro-5-<(β-dimethylamino)-vinyl>-4-nitroanisole 
• 63762-72-1 6-chloro-5-methoxy-1H-indole 
• 122509-72-2 6-Chloro-5-fluoro-1H-indole 
• 1242339-43-0 5-chloro-4-fluoro-2-methylphenylamine 
• 62492-46-0 5-chloro-4-methoxy-2-methylaniline 
• 62492-45-9 2-nitro-4-chloro-5-methoxymethylbenzene 

Relevant academic research and scientific papers

Use of a modified Leimgruber-Batcho reaction to prepare 6-chloro-5-fluoroindole

An efficient synthesis of the title indole, the heterocyclic core of the standard 5-HT2C receptor agonist Ro 60-0175, via a modified Leimgruber-Batcho indole synthesis is presented. The process can be used to make > 100 g quantities of the targ

Preparation method of 2,4,5-trifluorophenylacetic acid

The invention belongs to the technical field of preparation of drug intermediates, and discloses a preparation method of 2,4,5-trifluorophenylacetic acid, wherein the preparation method comprises the steps: step 1, reacting raw materials, a quaternary ammonium salt catalyst, sulfolane and potassium fluoride to obtain a first intermediate; step 2, carrying out hydrogenation catalytic reaction on the first intermediate to obtain a second intermediate; step 3, carrying out salt forming reaction on the second intermediate and a fluorinating reagent, quenching, and carrying out diazotization reaction on the second intermediate and a sodium nitrite aqueous solution to obtain diazonium salt; step 4, carrying out high-temperature cracking on the diazonium salt, to obtain 2,4,5-trifluorotoluene; and step 5 to step 7, carrying out halogenation, cyanidation and hydrolysis reactions on 2,4,5-trifluorotoluene in sequence, and thus obtaining 2,4,5-trifluorophenylacetic acid. The raw materials adopted by the method are easy to obtain and low in cost, the yield of the corresponding product obtained in each step is high, and large-scale production of the 2,4,5-trifluorophenylacetic acid is facilitated.

ANTITUMOR-EFFECT ENHANCER USING PYRAZOLO[3,4-D]PYRIMIDINE COMPOUND

To provide a method for treating cancer using a pyrazolo[3,4-d]pyrimidine compound or a salt thereof. The present invention provides an antitumor agent comprising a pyrazolo[3,4-d]pyrimidine compound of formula (I) wherein X, Y, Z1, Z2/su

NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUND OR SALT THEREOF

To provide a novel compound having a HER2 inhibitory effect and having a cytostatic effect. It is also intended to provide a medicament useful in the prevention and/or treatment of a disease involving HER2, particularly, cancer, on the basis of the HER2 i

Indoline derivatives as 5-HT2C receptor agonists

A series of 1-(1-indolinyl)-2-propylamines was synthesised and evaluated as 5-HT2C receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand

Indoline derivatives as 5-HT2B and or 5-HTC receptor ligands

For use in therapy a chemical compound of formula (I), wherein R1to R3are independently selected from hydrogen and alkyl; R4to R7are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, heterocyclyl, alkoxy, aryloxy, alkylthio, arylthio, alkylsulfoxyl, alkylsulfonyl, arylsulfoxyl, arylsulfonyl, amino, monoalkylamino, dialkylamino, nitro, cyano, carboxaldehyde, alkylcarbonyl, arylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonylamino, aminocarbonyloxy, monoalkylaminocarbonyloxy, dialkylaminocarbonyloxy, monoalkylaminocarbonylamino and dialkylaminocarbonylamino, wherein at least one of R4to R7is a substituent group other than hydrogen, and pharmaceutically acceptable salts and prodrugs thereof, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and especially for the treatment of obesity; chemical compounds of formula (I) other than compounds wherein R7is hydroxy.