709023-21-2

Basic information

• Product Name: 1-(5-chloro-2-nitro-phenyl)-3-methyl-piperazine
• Synonyms: 1-(5-chloro-2-nitro-phenyl)-3-methyl-piperazine
• CAS NO: 709023-21-2
• Molecular Weight: 255.704
• Mol File: 709023-21-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(5-chloro-2-nitro-phenyl)-3-methyl-piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-chloro-2-nitro-phenyl)-3-methyl-piperazine(709023-21-2)
• EPA Substance Registry System: 1-(5-chloro-2-nitro-phenyl)-3-methyl-piperazine(709023-21-2)

Safety Data

• Hazardous Substances Data: 709023-21-2(Hazardous Substances Data)

Upstream product

• 700-37-8 4-chloro-2-fluoro-nitrobenzene 
• 109-07-9 (RS)-2-methylpiperazine 

Downstream Products

• 745031-34-9 {4-[5-chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-2-methyl-piperazin-1-yl}-acetic acid ethyl ester 
• 556113-62-3 {4-[5-chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-2-methyl-piperazin-1-yl}-acetic acid 
• 745031-25-8 1-[5-chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-3-methyl-piperazine 
• 745031-24-7 4-chloro-2-(3-methyl-piperazin-1-yl)-phenylamine 

Relevant articles and documents

The synthesis and SAR of 2-arylsulfanyl-phenyl piperazinyl acetic acids as glyT-1 inhibitors

Elevation of glycine levels and activation of the NMDA receptor by inhibition of the glycine transporter 1 (GlyT-1) is a potential strategy for the treatment of schizophrenia. A novel series of GlyT-1 inhibitors have been identified containing the 2-arylsulfanyl-phenylpiperazine motif. The most prominent member of this series, (R)-4-[5-chloro-2-(4-methoxy-phenylsulfanyl)- phenyl]-2-methyl-piperazin-1-yl-acetic acid (31) is a potent glycine transporter-1 inhibitor (IC50=150nM), which elevated glycine levels in rat ventral hippocampus as measured by microdialysis in vivo at doses of 1.2-4.6mg/kg s.c.