709030-19-3Relevant academic research and scientific papers
Thiazole derivatives as inhibitors of cyclooxygenases in vitro and in vivo
El-Achkar, Ghewa A.,Jouni, Mariam,Mrad, May F.,Hirz, Taghreed,El Hachem, Nehme,Khalaf, Ali,Hammoud, Soukaina,Fayyad-Kazan, Hussein,Eid, Assaad A.,Badran, Bassam,Merhi, Raghida Abou,Hachem, Ali,Hamade, Eva,Habib, A?da
supporting information, p. 66 - 73 (2015/02/19)
Cyclooxygenases (COXs) are important membrane-bound heme containing enzymes important in platelet activation and inflammation. COX-1 is constitutively expressed in most cells whereas COX-2 is an inducible isoform highly expressed in inflammatory condition
Synthesis of 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and derivatives as potent and long-acting peripheral inhibitors of catechol-O-methyltransferase
Learmonth, David A.,Vieira-Coelho, Maria A.,Benes, Jan,Alves, Paula C.,Borges, Nuno,Freitas, Ana P.,Soares-da-Silva, Patrício
, p. 685 - 695 (2007/10/03)
A homologous series of novel nitro-catechol structures (7a-7e) were synthesized and tested as inhibitors of the enzyme catechol-O-methyltransferase (COMT). Increasing chain length was found to have significant impact on both brain penetration and duration
