70904-76-6

Upstream product

• 13257-67-5 2-amino-2-methylpropionic acid methyl ester 
• 79755-77-4 Z-Aib-Pro-Aib-D-Ala-OH 
• 79755-77-4 Z-Aib-Pro-Aib-Ala-OH 
• 15030-72-5 Z-Aib-OH 
• 172992-11-9 (S)-2-{1-[(S)-1-(1-Methoxycarbonyl-1-methyl-ethylcarbamoyl)-ethylcarbamoyl]-1-methyl-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid benzyl ester 
• 89045-42-1 Z-Aib-L-Ala-Aib-OMe 
• 112142-82-2 N-benzyloxycarbonyl-L-alanyl-2-aminoisobutyric acid methyl ester 
• 72086-78-3 L-alanyl-α-aminoisobutyric acid methyl ester 
• 65148-45-0 Z-Aib-Pro-Aib-Ala-OMe 
• 65148-45-0 (R)-2-(2-{[1-(2-Benzyloxycarbonylamino-2-methyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-2-methyl-propionylamino)-propionic acid methyl ester 
• 78569-65-0 Z-Aib-Pro-Aib-OH 
• 58281-75-7 Z-Aib-Pro-OH 

Downstream Products

• 186507-99-3 Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln(Trt)-Aib-Val-Aib-Gly-OMe 

Relevant academic research and scientific papers

Efficient synthesis of alamethicin F-30 using a chloro imidazolidium coupling reagent, CIP

Alamethicin F-30 has been synthesized in solution using a CIP-additive as a coupling agent and TFA as a final deprotecting reagent. All couplings including those between sterically hindered α,α-dimethyl amino acid were successfully achieved by a 60 min re

RACEMIZATION AT PROLINE RESIDUES DURING PEPTIDE BOND FORMATION A STUDY OF DIASTEREOMERIC MIXTURES OF SYNTHETIC ALAMETHICIN FRAGMENTS BY 270 MHz 1H NMR

The stepwise synthesis of amino terminal pentapeptide of alamethicin, Z-Aib-Pro-Aib-Ala-Aib-OMe, by the dicyclohexylcarbodiimide mediated couplings leads to extensive racemization at the Ala and Pro residues.Racemization is largely suppressed by the use o