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70908-61-1

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70908-61-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 70908-61-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,9,0 and 8 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 70908-61:
(7*7)+(6*0)+(5*9)+(4*0)+(3*8)+(2*6)+(1*1)=131
131 % 10 = 1
So 70908-61-1 is a valid CAS Registry Number.

70908-61-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Diethyl ({[(benzyloxy)carbonyl]amino}methyl)phosphonate

1.2 Other means of identification

Product number -
Other names diethyl N-(benzyloxycarbonyl) amidomethyl phosphonate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:70908-61-1 SDS

70908-61-1Relevant articles and documents

The relative catalytic efficiency of β-lactamase catalyzed acyl and phosphyl transfer

Slater, Martin J.,Laws, Andrew P.,Page, Michael I.

, p. 77 - 95 (2007/10/03)

Phosphonamidates which bear a simple resemblance to penicillin type structures have been synthesised as potential inhibitors of β-lactamases: -ethyl N-(benzyloxycarbonyl) amidomethyl phosphonyl amides, PhCH2OCONHCH2P(O)(OEt)NR2, the amines HNR2 being L-proline, D-proline, L-thiazolidine, and o-anthranilic acid. The proline derivatives completely and irreversibly inactivated the class C β-lactamase from Enterobacter cloacae P99, in a time-dependent manner, indicative of covalent inhibition. The inactivation was found to be exclusive to the class C enzyme and no significant inhibition was observed with any other class of β-lactamase. The anthranilic acid derivative exhibited no appreciable inactivation of the β-lactamases. The phosphonyl proline and phosphonyl thioproline derivatives were separated into their diastereoisomers and their individual second order rate constants for inhibition were found to be 7.72 ± 0.37 and 8.3 × 10-2 ± 0.004 M-1 s-1 for the L-proline derivatives, at pH 7.0. The products of the inhibition reaction of each individual diastereoisomer, analyzed by electrospray mass spectroscopy, indicate that the more reactive diastereoisomers phosphonylate the enzyme by P-N bond fission with the elimination of proline. Conversely, gas chromatographic detection of ethanol release by the less reactive proline diastereoisomer suggests phosphonylation occurs by P-O bond fission. The enzyme enhances the rate of phosphonylation with P-N fission by at least 106 compared with that effected by hydroxide-ion. The pH dependence of the rate of inhibition of the β-lactamase by the more reactive diasteroisomer is consistent with the reaction of the diprotonated form of the enzyme, EH2, with the inhibitor, I (or its kinetic equivalents EH with IH). This pH dependence and the rate enhancement indicate that the enzyme appears to use the same catalytic apparatus for phosphonylation as that used for hydrolysis of β-lactams. The stereochemical consequences of nucleophilic displacement at the phosphonyl centre are discussed.

Phosphonyltriethylammonium salts: Novel reactive species for the synthesis of phosphonate esters and phosphonamides

Hirschmann, Ralph,Yager, Kraig M.,Taylor, Carol M.,Moore, William,Sprengeler, Paul A.,Witherington, Jason,Phillips, Barton W.,Smith III, Amos B.

, p. 6370 - 6371 (2007/10/02)

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α-Substituted Phosphonates. 37. Derivatives of α-Pyrrolomethanephosphonic Acid and N-Vinylpyrroles

Gross, H.,Beisert, S.,Costisella, B.

, p. 877 - 886 (2007/10/02)

Diethyl α-aminomethanephosphonate 5a and its α-aryl derivatives 5b-d react with 2,5-diethoxytetrahydrofuran 1 to give diethyl α-pyrrolomethanephosphonate 9a and the α-aryl derivatives 9b-d, respectively.The pyrrolo derivatives 9 can be converted into the lithium salts 15 and 16, respectively, which with carbonyl compounds undergo the Horner reaction yielding E/Z mixtures of N-vinylpyrroles 18.In certain cases the intermediate of the Horner reaction, the β-hydroxyphosphonate, 17 can be isolated.The pyrrolo-analogue of stilbene, 18a, is formed only as E-isomer.On treating the lithium salts 15 and 16 with 9 or with alkyl halides α-C-alkylated pyrrolophosphonates 22 and 23, respectively, are obtained.

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