70916-98-2Relevant academic research and scientific papers
Mixed donor, phenanthroline photoactive MOFs with favourable CO2selectivity
Setter, Caitlin J.,Price, Michael B.,Conte, Luke,Schmitt, Wolfgang,Batten, Stuart R.,Richardson, Christopher,Hill, Matthew R.,Babarao, Ravichandar,MacReadie, Lauren K.
, p. 13377 - 13380 (2020)
Mixed donor phenanthroline-carboxylate linkers were combined with MnII or ZnII to form photoactive MOFs with large pore apertures. The MOFs display high CO2 adsorption capacities, which consequently causes structural framework flexibility, and align with
Using geometric simulation software 'GASP' to model conformational flexibility in a family of zinc metal-organic frameworks
Gee, William J.,Wells, Stephen A.,Teat, Simon J.,Raithby, Paul R.,Burrows, Andrew D.
, p. 8728 - 8737 (2021)
Here, a new tripodal tricarboxylic acid ligand, 4,4′-(4′-(4′-carboxy-[1,1′-biphenyl]-4-yl)-[2,2′:6′,2′′-terpyridine]-5,5′′-diyl)-dibenzoic acid (H3cbt), was synthesised using a three-step convergent strategy. Subsequent reactions with zinc(ii) nitrate hexahydrate yielded three metal-organic frameworks (MOFs). The three MOFs, [Zn(Hcbt)]·4DMF (1), [Zn(Hcbt)]·4DMSO·1.5H2O·DMF (2), and [Zn(Hcbt)]·2DMF·3H2O (3), each adopt flexible interdigitated 2D net topologies. Framework 1 has DMF-filled channels that retain porosity upon desolvation, with a measured BET surface area of 248 m2 g-1. Framework 2 possesses larger DMSO-containing channels that collapse upon desolvation, resulting in near-equivalent porosity values to framework 1. In silico calculations and topological considerations determined using the geometric simulation software GASP dictate that framework 2 can feasibly alter conformation to approximate 1, but cannot perfectly replicate the interdigitated motif. Framework 3 formed when wet solvents were used to synthesise 1. Interestingly, the interdigitated structure of 3 contains a unique carboxylate binding mode that precludes its subsequent adoption by either 1 or 2 upon their exposure to water. This diverse array of structural considerations recommends this MOF family for modelling using GASP. Interrogating frameworks 1-3 using this software provided insights that justified experimentally observed conformational trends, as well as barriers to interconversion between members of this MOF family. In a broader sense, this work demonstrates the wider applicability of GASP software to modelling structural changes within flexible MOF materials.
Mimics of Pincer Ligands: An Accessible Phosphine-Free N-(Pyrimidin-2-yl)-1,2-azole-3-carboxamide Framework for Binuclear Pd(II) Complexes and High-Turnover Catalysis in Water
Bumagin, Nikolay A.,Dikusar, Evgenij A.,Ivashkevich, Ludmila S.,Kletskov, Alexey V.,Kolesnik, Iryna A.,Lyakhov, Alexander S.,Petkevich, Sergey K.,Potkin, Vladimir I.
supporting information, (2020/08/12)
We report for the first time cyclic phosphine-free "head to tail"N,N,N pincer-like (pincer complexes mimicking) N-(pyrimidin-2-yl)-1,2-azole-3-carboxamide Pd(II) complexes with deprotonated amide groups as high-turnover catalysts (TON up to 106, TOF up to 1.2 × 107 h-1) for cross-coupling reactions on the background of up to quantitative yields under Green Chemistry conditions. The potency of the described catalyst family representatives was demonstrated in Suzuki-Miyaura, Mizoroki-Heck, and Sonogashira reactions on industrially practical examples. Corresponding ligands could be synthesized based on readily available reagents through simple chemical transformations. Within the complex structures, a highly unusual 1,3,5,7-tetraza-2,6-dipalladocane frame could be observed.
THE PREPARATION METHOD OF 4’-FORMYL-4-BIPHENYLCARBOXYLIC ACID
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Paragraph 0018; 0028-0030; 0032; 0034, (2019/01/04)
The present invention relates to a novel method for manufacturing 4andprime;-formyl-4-biphenylcarboxylic acid, which is useful as a liquid crystal, liquid crystal polymer, and high heat-dissipating and high heat-resistant resin material, from 4,4andprime;-bis(chloromethyl)biphenyl which is commercially available. Through an oxidation reaction, 4,4andprime;-bis(chloromethyl)biphenyl is converted into 4andprime;-formyl-4-biphenylcarboxylic acid.COPYRIGHT KIPO 2018
Design, synthesis and antiproliferative activities evaluation of thiazolopyrimidines derivatives through biginelli reaction
Zhu, Pengju,Fu, Huansheng,Fang, Hao
, p. 1382 - 1390 (2017/12/28)
Background: Thiazolopyrimidines possessed their structural diversity and various biological activity. Up to date, thiazolopyrimidines derivatives have widespread applications in pharmaceutical fields. In this article, a series of thiazolopyrimidine derivatives were designed based on the lead compound structure in our previous studies. Methods: All the target compounds were synthesized with the coupling reaction, Biginelli reaction and “one-pot” aldol condensation. Their structures were identified by1H NMR,13C NMR spectra and HRMS. Antitumor activities of the target compounds were evaluated by MTT. Results: 25 new target compounds were synthesized and they primarily screened through testing their inhibitory rates against two human tumor cell lines and Compounds 15, 17, 20, 22, 40 exhibited more than 70% inhibitory rate against both MDA-MB-231 and K562. Further assessing their IC50 against five tumor cell lines, 15 and 22 show advantage over lead compound I in MDA-MB-231, K562 and PC-3. Conclusion: A series of thiazolopyrimidine derivatives were synthesized and the preliminary biological evaluation suggest that target compound 22 exhibited better antiproliferative activity against K562 than gossypol.
Palladium supported on aminopropyl-functionalized polymethylsiloxane microspheres: Simple and effective catalyst for the Suzuki-Miyaura C-C coupling
Zawartka, Wojciech,P?piech, Piotr,Cypryk, Marek,Trzeciak, Anna M.
, p. 230 - 235 (2015/07/28)
Abstract A palladium catalyst, obtained in the reaction of PdCl2(MeCN)2 with microspheric aminopropyl polymethylsiloxane, was used in the Suzuki-Miyaura cross-coupling of various aryl bromides with phenylboronic acids. Catalytic reactions, performed at 80°C in a 2-propanol/water mixture, led to high yields of non-symmetric biphenyls. In recycling experiments, excellent results (up to 100%) were obtained in ten subsequent runs. Efficient separation of the catalyst from organic products was achieved by simple filtration due to the properties of microspheres.
Design and synthesis of new nanosized C 3-symmetrical tricarboxylic acids: Key elongated ligands for the preparation of highly porous MOFs
Markoulides, Marios S.,Efthymiou, Constantinos G.,Tasiopoulos, Anastasios J.,Chronakis, Nikos
supporting information, p. 2659 - 2662 (2015/11/27)
The synthesis of two new C 3-symmetrical nanosized tricarboxylic acids bearing triphenylmethane cores and three imines linkages is presented. The new elongated tripods were designed to stabilise highly porous metal-organic frameworks (MOFs) and
Synthesis and characterization of new tetra-substituted porphyrins with exo-donor carboxylic groups as building blocks for supramolecular architectures. Catalytic and structural studies of their metalated derivatives
Carlucci, Lucia,Ciani, Gianfranco,Maggini, Simona,Proserpio, Davide M.,Ragaini, Fabio,Gallo, Emma,Ranocchiari, Marco,Caselli, Alessandro
, p. 804 - 814 (2011/09/15)
We report herein the synthesis of the porphyrins 5,10,15,20-tetrakis(4- carboxybiphenyl)-porphyrin (H2TCBP) and 5,10,15,20-tetrakis(4- carboxy-2,6-dimethylbiphenyl)porphyrin (H2TCDMBP) bearing diphenyl units on meso-positions, and of
