7093-67-6Relevant articles and documents
Mechanochemical Prebiotic Peptide Bond Formation**
Cindro, Nikola,Grube?i?, Sa?a,Hernández, José G.,Me?trovi?, Ernest,Stolar, Tomislav,U?arevi?, Krunoslav
supporting information, p. 12727 - 12731 (2021/05/07)
The presence of amino acids on the prebiotic Earth, either stemming from endogenous chemical routes or delivered by meteorites, is consensually accepted. Prebiotically plausible pathways to peptides from inactivated amino acids are still unclear as most oligomerization approaches rely on thermodynamically disfavored reactions in solution. Now, a combination of prebiotically plausible minerals and mechanochemical activation enables the oligomerization of glycine at ambient temperature in the absence of water. Raising the reaction temperature increases the degree of oligomerization concomitantly with the formation of a commonly unwanted cyclic glycine dimer (DKP). However, DKP is a productive intermediate in the mechanochemical oligomerization of glycine. The findings of this research show that mechanochemical peptide bond formation is a dynamic process that provides alternative routes towards oligopeptides and establishes new synthetic approaches for prebiotic chemistry.
PEPTIDE FORMATION FROM AMINO ACID WITH PARTICULATE SEMICONDUCTOR PHOTOCATALYSTS
Onoe, Jun,Kawai, Tomoji,Kawai, Shichio
, p. 1667 - 1670 (2007/10/02)
Peptides of diglycine to pentaglycine are formed from glycine under irradiation in the presence of particulate semiconductor photocatalysts such as TiO2, CdS, CdSe, MoS2, In2O3, and GaP, with and without Pt deposition.Platinization of the semiconductors efficiently enhanced the yield of the peptides.
