7093-67-6

Usage

Uses

Used in Pharmaceutical Industry:
PENTAGLYCINE is used as a tumor necrosis factor receptor 2 agonist for its potential role in modulating immune responses and treating certain medical conditions. Its specific interaction with the receptor may provide therapeutic benefits in targeted treatments.
Used in Research and Development:
PENTAGLYCINE, due to its unique structure and properties, can be utilized in research and development for understanding the mechanisms of various biological processes and the development of new drugs or therapies. Its role as a pentapeptide may offer insights into peptide-based drug design and synthesis.
Used in Drug Delivery Systems:
Similar to other peptides, PENTAGLYCINE can be employed in drug delivery systems to improve the targeting and efficacy of therapeutic agents. Its small size and specific interactions with receptors may allow for the development of novel drug carriers or targeted drug delivery methods.

InChI:InChI=1/C10H17N5O6/c11-1-6(16)12-2-7(17)13-3-8(18)14-4-9(19)15-5-10(20)21/h1-5,11H2,(H,12,16)(H,13,17)(H,14,18)(H,15,19)(H,20,21)

Upstream product

• 114258-31-0 N-chloroacetyl-glycyl=>glycyl=>glycyl=>glycine 
• 56-40-6 glycine 
• 556-33-2 glycine-glycine-glycine 
• 637-84-3 tetraglycine 
• 104186-69-8 2-{2-[2-(2-chloroacetamido)acetamido]acetamido}acetic acid 
• 15474-96-1 chloroacetyldiglycine 
• 106-57-0 Glycine anhydride 
• 556-50-3 glycylglycine 
• 38126-71-5 H-(Gly)4-OH hydrochloride 

Downstream Products

• 56-40-6 glycine 
• 916849-20-2 p-[N-(4-pentaglycyl-2,3-dioxocyclobut-1-enyl)amino]phenyl α-D-mannopyranoside 
• 100-02-7 4-nitro-phenol 
• 128891-33-8 N-acetylglycine pentamer 

Relevant academic research and scientific papers

Mechanochemical Prebiotic Peptide Bond Formation**

The presence of amino acids on the prebiotic Earth, either stemming from endogenous chemical routes or delivered by meteorites, is consensually accepted. Prebiotically plausible pathways to peptides from inactivated amino acids are still unclear as most oligomerization approaches rely on thermodynamically disfavored reactions in solution. Now, a combination of prebiotically plausible minerals and mechanochemical activation enables the oligomerization of glycine at ambient temperature in the absence of water. Raising the reaction temperature increases the degree of oligomerization concomitantly with the formation of a commonly unwanted cyclic glycine dimer (DKP). However, DKP is a productive intermediate in the mechanochemical oligomerization of glycine. The findings of this research show that mechanochemical peptide bond formation is a dynamic process that provides alternative routes towards oligopeptides and establishes new synthetic approaches for prebiotic chemistry.

Spontaneous and promoted association of linear oligoglycines

Linear oligoglycines of various lengths bearing a carboxyl or an amide group at their C-termini and also their poly(acrylamide) conjugates were synthesized. No self-assembly into supramolecular structures was observed for free oligoglycines H-(Gly)m-OH (m = 3-5). At the same time, oligoglycylamides H-(Gly)m-NH2 (m = 3-5) demonstrated ability for both self-assembly in aqueous solution and assembly promoted by an additional interaction with surface. In the case of polymer-bound oligoglycines (and their amides), no intramolecular clustering of peptide chains, as expected, was observed. This means that the presence of several oligoglycine chains bound to each other in one center is not a necessary prerequisite for polyglycine II-type association. Pleiades Publishing, Inc., 2006.

PEPTIDE FORMATION FROM AMINO ACID WITH PARTICULATE SEMICONDUCTOR PHOTOCATALYSTS

Peptides of diglycine to pentaglycine are formed from glycine under irradiation in the presence of particulate semiconductor photocatalysts such as TiO2, CdS, CdSe, MoS2, In2O3, and GaP, with and without Pt deposition.Platinization of the semiconductors efficiently enhanced the yield of the peptides.