70930-22-2Relevant academic research and scientific papers
Transition-metal ion-mediated morphological transformation of pyridine-based peptide nanostructures
Singh, Narendra,Singh, Ramesh,Sharma, Swati,Kesharwani, Khushboo,Joshi, Khashti Ballabh,Verma, Sandeep
, p. 153 - 161 (2021)
Inspired by natural metallopeptides, we have rationally designed two pyridine-conjugated short peptides. These two peptide conjugates formed a pair of constitutional isomers that helped us describe their structure-function relationship. Both the isomers consisted of an equal number of aromatic amino acid residues, but shuffling was observed in the position of two key amino acids, viz; tyrosine and phenylalanine, which brought a remarkable change in their self-assembling behavior. The presence of specific functional groups and chemical diversity in both conjugates made them very active towards metal coordination. Both the constitutional isomers adopted different pathways of self-assembly, which could be further controlled or transformed by the use of transition metal ions. Interestingly, it was observed that the metal ions could precisely control the morphology of these metallopeptide nanostructures and make them more stable. Therefore, such artificial metallopeptides possess remarkable advantages over the natural counterparts primarily due to their tailor-made chemical structures.
Direct structural comparison of a rigid cyclic peptidic scaffold using crystallography and NMR in strained PH polymer gels
Arnusch, Christopher J.,Ippel, Johannes H.,Kooijman, Huub,Spek, Anthony L.,Liskamp, Rob M. J.,Kemmink, Johan,Pieters, Roland J.
experimental part, p. 4501 - 4507 (2010/10/02)
A small series of biaryl ether containing cyclic peptidic scaffolds was synthesized and cyclized by an SNAr reaction. The structure of one rigid scaffold was solved, by X-ray crystallography and also determined in solution by NMR spectroscopy. Molecular a
