70934-09-7

Usage

Chemical compound

2-amino-6,7,8,9-tetrahydro-11Hpyrido[2,1-b]quinazolin-11-one

Class

Quinazolinone derivative

Structure

Heterocyclic compound with a nitrogen atom

Application

Used in pharmaceutical industry for drug synthesis

Biological activities

Anti-cancer, anti-inflammatory, anti-microbial

Molecular structure

Unique

Potential

Promising candidate for new drug development and therapeutic agents

Upstream product

• 2446-62-0 7,8,9-trihydropyrido[2,1-b]quinazolin-11(6H)-one 

Downstream Products

• 1446320-20-2 8-acetylamino-4-(3',4'-dimethoxybenzylidene)mackinazolinone 
• 1446320-28-0 8-[(4'-nitrobenzylidene)amino]-4-(4-nitrobenzylidene)mackinazolinone 
• 1446320-16-6 8-acetylamino-4-benzylidenemackinazolinone 
• 1446320-17-7 8-acetylamino-4-(4'-hydroxybenzylidene)mackinazolinone 
• 1446320-18-8 8-acetylamino-4-(4'-dimethylaminobenzylidene)mackinazolinone 
• 1446320-19-9 8-acetylamino-4-(4'-nitrobenzylidene)mackinazolinone 
• 98832-58-7 8-benzoylaminomackinazolinone 
• 1446320-22-4 8-benzoylamino-4-benzylidenemackinazolinone 
• 1446320-23-5 8-benzoylamino-4-(4-hydroxybenzylidene)mackinazolinone 
• 1446320-24-6 8-benzoylamino-4-(4-dimethylaminobenzylidene)mackinazolinone 
• 1446320-25-7 8-benzoylamino-4-(4-nitrobenzylidene)mackinazolinone 
• 1446320-26-8 8-benzoylamino-4-(3,4-dimethoxybenzylidene)mackinazolinone 
• 1446320-27-9 8-benzoylamino-4-(furfurylidene-2)mackinazolinone 
• 1446320-15-5 8-[(4'-nitrobenzylidene)amino]mackinazolinone 

Relevant academic research and scientific papers

Synthesis of 8-amino- and 8-acetyl(benzoyl) aminomackinazolinones and their condensation with aldehydes

Methods for preparing of 8-nitro- and 8-aminomackinazolinones were improved. 8-Acetyl(benzoyl)aminomackinazolinones reacted smoothly with aromatic aldehydes and furfurol in glacial acetic acid to give the corresponding 4-arylidene-substituted derivatives. Reaction of 8-aminomackinazolinone with aromatic aldehydes in glacial acetic acid was accompanied by acetylation of the amine and gave 8-acetylamino-4-arylidenemackinazolinones. Reaction of 8-aminomackinazolinone and p-nitrobenzaldehyde in propionic acid produced 8-[(4' -nitrobenzylidene)amino]-4-(4'-nitrobenzylidene)mackinazolinone. In contrast, the reaction in Py occurred selectively at the amine to form the corresponding Schiff base 8-[(4'-nitrobenzylidene)amino]mackinazolinone.