7094-34-0

Usage

InChI:InChI=1/C13H8Cl2O/c14-11-5-1-3-9(7-11)13(16)10-4-2-6-12(15)8-10/h1-8H

Upstream product

• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 24691-69-8 Sb(C₆H₄Cl-m)3 
• 108-37-2 1-bromo-3-chlorobenzene 
• 541-41-3 chloroformic acid ethyl ester 
• 587-04-2 m-Chlorobenzaldehyde 
• 64-18-6 formic acid 
• 625-99-0 3-iodochlorobenzene 
• 63503-60-6 3-chlorophenylboronic acid 
• 618-46-2 m-Chlorobenzoyl chloride 
• 79-37-8 oxalyl dichloride 
• 33756-91-1 tris(3-chlorophenyl)bismuthane 
• 1248383-99-4 C₁₈H₁₂Cl₃In 
• 35190-07-9 1,2-bis(3-chlorophenyl)ethane-1,2-dione 

Downstream Products

• 1027545-06-7 3,3-bis-(3-chloro-phenyl)-oxirane-2-carboxylic acid ethyl ester 
• 35190-12-6 bis(3-chlorophenyl)methanol 
• 656806-83-6 bis(3-chlorophenyl)-dichloromethane 
• 120553-26-6 (E)-5,5-Bis-(3-chloro-phenyl)-penta-2,4-dienoic acid 
• 120553-40-4 (E)-5,5-bis(3-chlorophenyl)-2,4-pentadienoic acid 4-nitrophenyl ester 
• 121802-25-3 1-[Benzo[b]thiophen-3-yl-bis-(3-chloro-phenyl)-methyl]-1H-imidazole 
• 121802-20-8 3-[Chloro-bis-(3-chloro-phenyl)-methyl]-benzo[b]thiophene 
• 1026686-70-3 3,3-bis-(3-chloro-phenyl)-oxirane-2-carboxylic acid 

Relevant academic research and scientific papers

Method for preparing symmetric diarylketone through catalytic oxidative carbonylation

The invention discloses a method for preparing symmetric diarylketone of a formula (I) as shown in the description. The method comprises the following steps: mixing arylboronic acid (II) (Ar-B(OH)2 (II)), a palladium catalyst, a promoter and an organic solvent in a reactor, introducing air and CO having a volume ratio of (7-19):1, reacting under the conditions of a pressure of 1-6 atm and a temperature of 30-80 DEG C for 8-16 hours, and performing after-treatment on the reaction solution, thereby obtaining the product symmetric diarylketone. According to the method disclosed by the invention,the air directly serves as an oxidizing agent to replace the O2 to be applied to oxidative carbonylation of the arylboronic acid, and the ratio of the air to CO is beyond an explosion limit. Therefore, the catalytic system is safe and economic. The palladium catalyst is small in dosage and simple in separation and can be recycled for several times. The method disclosed by the invention is mild inreaction condition, excellent in substrate suitability and high in yield.

Palladium-Catalyzed Carbonylative Homocoupling of Aryl Iodides for the Synthesis of Symmetrical Diaryl Ketones with Formic Acid

A convenient method for the palladium-catalyzed carbonylative homocoupling of aryl iodides was developed. With formic acid as the CO source, various symmetrical diaryl ketones were synthesized in moderate to good yield in the presence of a palladium catalyst.

AZA-PYRIDONE COMPOUNDS AND USES THEREOF

Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.

Palladium-catalyzed oxidative carbonylation for the synthesis of symmetrical diaryl ketones at atmospheric co pressure

A mild and efficient synthesis of symmetrical diaryl ketones by palladium-catalyzed oxidative carbonylation of arylboronic acids with carbon monoxide at atmospheric pressure is reported. Georg Thieme Verlag Stuttgart New York.

Pd/Cu-cocatalyzed aerobic oxidative carbonylative homocoupling of arylboronic acids and CO: A highly selective approach to diaryl ketones

A highly selective Pd/Cu-cocatalyzed aerobic oxidative carbonylative homocoupling of arylboronic acids has been developed. This method employs a simple catalytic system, readily available boronic acids as the substrates, molecular oxygen as the oxidant, and 1 atm of CO/O2, which makes this method practical for further applications.

Phosphine ligand triggered oxidative decarbonylative homocoupling of aromatic aldehydes: Selectively generating biaryls and diarylketones

A novel rhodium-catalyzed oxidative decarbonylative homocoupling of aromatic aldehydes to generate biaryls and diarylketones selectively and efficiently, triggered by the choice of different phosphine ligands.

Oxalyl chloride as carbonyl synthon in Pd-catalyzed carbonylations of triarylbismuth and triarylindium organometallic nucleophiles

Oxalyl chloride has been demonstrated to function as C1 carbonyl synthon in the carbonylations of triarylbismuth and triarylindium nucleophiles under palladium-catalyzed conditions. All the three aryl groups from both bismuth and indium reagents participated in carbonylative couplings to afford the corresponding functionalized ketones in high yields. This study also disclosed a novel utilization of oxalyl chloride as facile alternative source of CO for carbonylations under palladium catalysis.

Indole synthesis: palladium-catalyzed C-H bond amination via reduction of nitroalkenes with carbon monoxide

Nitroalkenes have been called 'chemical chameleons' due to their versatility in numerous synthetic transformations. Herein, we describe the first transition metal-catalyzed transformation of conjugated nitroalkenes into indoles. Under mild reaction condit

Kinetics of the solvolyses of benzhydryl derivatives: Basis for the construction of a comprehensive nucleofugality scale

A series of 21 benzhydrylium ions (diarylmethylium ions) are proposed as reference electrofuges for the development of a general nucleofugality scale, where nucleofugality refers to a combination of leaving group and solvent. A total of 167 solvolysis rate constants of benzhydrylium tosylates, bromides, chlorides, trifluoroacetates, 3,5-dinitrobenzoates, and 4-nitroben-zoates, two-thirds of which have been determined during this work, were subjected to a least-squares fit according to the correlation equation log k 25°C = Sf(Nf + Ef), where s f and Nf are nucleofuge-specific parameters and E f is an electrofuge-specific parameter. Although nucleofuges and electrofuges characterized in this way cover more than 12 orders of magnitude, a single set of the parameters, namely sf, Nf, and E f, is sufficient to calculate the solvolysis rate constants at 25°C with an accuracy of ± 16%. Because sf ≈ 1 for all nucleofuges, that is, leaving group/ solvent combinations, studied so far, qualitative discussions of nucleofugality can be based on Nf.

Dications of fluorenylidenes. The relationship between redox potentials and antiaromaticity for meta- and para-substituted diphenylmethylidenefluorenes

Electrochemical oxidation of meta-substituted diphenylmethylidenefluorenes (3a-g) results in the formation of fluorenylidene dications that are shown to be antiaromatic through calculation of the nucleus independent chemical shift (NICS) for the 5- and 6-