70974-09-3Relevant articles and documents
N1- and N3-Arylations of Hydantoins Employing Diaryliodonium Salts via Copper(I) Catalysis at Room Temperature
Abha Saikia, Raktim,Barman, Dhiraj,Dutta, Anurag,Jyoti Thakur, Ashim
, p. 400 - 410 (2020/12/17)
Copper(I)-catalyzed N-arylation (both N1- and N3-) of hydantoins with diaryliodonium salts as aryl partners at room temperature is reported. The transformation allows diverse scopes on both hydantoins and diaryliodonium salts deliver
Copper-Mediated N-Arylations of Hydantoins
Thilmany, Pierre,Gérard, Phidéline,Vanoost, Agathe,Deldaele, Christopher,Petit, Laurent,Evano, Gwilherm
, p. 392 - 400 (2018/12/11)
A set of two broadly applicable procedures for the N-arylation of hydantoins is reported. The first one relies on the use of stoichiometric copper(I) oxide under ligand- A nd base-free conditions and enables a clean regioselective arylation at the N3 nitrogen atom, while the second one is based on the use of catalytic copper(I) iodide and trans-N,N′-dimethylcyclohexane-1,2-diamine and promotes arylation at the N1 nitrogen atom. Importantly, the combination of these two procedures affords a straightforward entry to diarylated hydantoins.
3-Arylhydantoine, a class of schistosomicidal compounds
Link,Stohler
, p. 261 - 265 (2007/10/02)
A series of derivatives of 3-arylhydantoin was synthesized and submitted to a broad pharmacological screening. Unexpectedly, some of the tested compounds showed interesting activity against infection with Schistosoma mansoni. From a study on structure-act
Antiandrogenic and schistosomicidal imidazolidine derivatives
-
, (2008/06/13)
Imidazolidine derivatives, as well as processes for their preparation, which have antiandrogenic and schistosomicidal activity.