1448631-99-9

Upstream product

• 636-98-6 p-nitrobenzene iodide 
• 1493-13-6 trifluorormethanesulfonic acid 
• 100-66-3 methoxybenzene 

Downstream Products

• 84249-27-4 C₁₀H₁₂N₂O₄ 
• 1423707-33-8 N-4-nitrophenyl-proline methyl ester 
• 1605291-17-5 N-4-nitrophenyl-β-phenylalanine methyl ester 
• 70974-09-3 5,5-dimethyl-3-(4-nitrophenyl)imidazolidine-2,4-dione 
• 92668-55-8 3-(4-methoxyphenyl)-5,5-dimethylimidazolidine-2,4-dione 
• 3112-80-9 bis(p-anisyl)sulfone 
• 32471-55-9 1-(1,1-difluoroethyl)-4-nitrobenzene 

Relevant academic research and scientific papers

Metal-free synthesis of ortho -CHO diaryl ethers by a three-component sequential coupling

A practical, metal-free, and highly chemoselective approach was developed for the synthesis of ortho-CHO diaryl ethers by a three-component sequential coupling of arynes, N,N-dimethylformamide (DMF), and diaryliodonium salts. Diverse functional groups including halo, nitryl, and bulky substituents and heteroaromatics are well tolerated. Mechanistically, isotopic tracer experiments reveal that the diaryliodonium salt serves as an electrophile to trap the transient intermediates generated from the [2 + 2] cyclization of an aryne and DMF.

Transition Metal-Free N-Arylation of Amino Acid Esters with Diaryliodonium Salts

A transition metal-free approach for the N-arylation of amino acid derivatives has been developed. Key to this method is the use of unsymmetric diaryliodonium salts with anisyl ligands, which proved important to obtain high chemoselectivity and yields. The scope includes the transfer of both electron deficient, electron rich and sterically hindered aryl groups with a variety of different functional groups. Furthermore, a cyclic diaryliodonium salt was successfully employed in the arylation. The N-arylated products were obtained with retained enantiomeric excess.