70981-48-5Relevant academic research and scientific papers
Hypoiodite-mediated cyclopropanation of alkenes
Yoshimura, Akira,Koski, Steven R.,Kastern, Brent J.,Fuchs, Jonathan M.,Jones, T. Nicholas,Yusubova, Roza Y.,Nemykin, Victor N.,Zhdankin, Viktor V.
supporting information, p. 5895 - 5898 (2014/05/20)
An efficient, transition metal-free procedure for the cyclopropanation of alkenes using malononitrile and the LiI-tBuOCl combination under mild reaction conditions is described. The reaction mechanism most likely involves tBuOI generated in situ from LiI and tBuOCl. The utility of this new methodology has been demonstrated by the synthesis of a potential HIV-1 RT inhibitor. An efficient, transition-metal-free procedure for the cyclopropanation of alkenes using malononitrile and the LiI/tBuOCl combination under mild reaction conditions is described. The reaction mechanism most likely involves tBuOI generated in situ from LiI and tBuOCl. The utility of this new methodology has been demonstrated by the synthesis of a potential HIV-1 RT inhibitor (see scheme).
Reactivity of β,β-γ,γ-tetracyanoalkanones, β,β-dicyanoalkanones, and 5-amino-4-cyano-2,3-dihydrofurans
Nasakin,Sheverdov,Moiseeva,Ershov,Chernushkin,Tafeenko
, p. 291 - 300 (2007/10/03)
Procedures were developed for preparing polyfunctional alicyclic and heterocyclic compounds from tetracyanoalkanones, dicyanoalkanones, and 5-amino-4-cyano-2,3-dihydrofurans. From β,β,γ,γ-tetracyanoalkanones we prepared 5-amino-3a,4-dicyano-2,3,3a,6a-tetr
