70988-03-3

Upstream product

• 25354-56-7 3-amino-3-(4-dimethylamino-phenyl)-acrylonitrile 
• 7647-01-0 hydrogenchloride 
• 64992-14-9 acetic 2-cyanoacetic anhydride 
• 121-69-7 N,N-dimethyl-aniline 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 75-05-8 acetonitrile 
• 1197-19-9 4-cyano-N,N-dimethylaniline 

Downstream Products

• 82791-84-2 2-benzylidene-3-(4-dimethylaminophenyl)-3-oxopropanenitrile 
• 1371534-49-4 6-(4-(dimethylamino)phenyl)-4-methyl-2-oxo-2H-pyran-3-carbonitrile 
• 1245836-02-5 7-amino-2-(4-(dimethylamino)phenyl)-5-phenylpyrazolo[1,5-a]pyrimidine-6-carbonitrile 
• 96219-77-1 3-(dimethylamino)-2-(4-(dimethylamino)benzoyl)acrylonitrile 
• 208519-11-3 3-(4-(dimethylamino)phenyl)-1H-pyrazol-5-amine 
• 82791-80-8 5-Amino-2-(4-dimethylamino-phenyl)-4-phenyl-furan-3-carbonitrile 

Relevant academic research and scientific papers

Modular synthesis and antiproliferative activity of new dihydro-1H-pyrazolo[1,3-b]pyridine embelin derivatives

A set of new dihydro-1H-pyrazolo[1,3-b]pyridine and pyrazolo[1,3-b]pyridine embelin derivatives was synthesized through a multicomponent reaction from natural embelin, 3-substituted-5-aminopyrazoles and aldehydes. The synthesized compounds were evaluated against three hematologic tumor cell lines, HEL (acute erythroid leukemia), K-562 (chronic myeloid leukemia) and HL-60 (acute myeloid leukemia), and five breast cancer cell lines (SKBR3, MCF-7, MDA-MB-231, BT-549, HS-578T). The primate non-malignant kidney Vero cell line was used as the control of cytotoxicity. From the obtained results, some structure–activity relationships were out-lined. Furthermore, in silico prediction of physicochemical properties and ADME parameters were determined for the derivatives with the best antiproliferative values.

Polysubstituted heterocyclic derivative, preparation method thereof and application of polysubstituted heterocyclic derivative in medicine

The invention provides a polysubstituted heterocyclic derivative, a preparation method thereof and application of the polysubstituted heterocyclic derivative in medicine, and belongs to the technical field of medicinal chemistry. The polysubstituted heterocyclic derivative is a compound shown in a general formula I or II, a pharmaceutically acceptable salt or a solvate of the compound, and the compound can inhibit mRNA demethylase on the protease level and is used for treating diseases related to mRNA demethylase functions.

Studies on 3-oxoalkanenitriles: Novel rearrangement reactions observed in studies of the chemistry of 3-heteroaroyl-3-oxoalkanenitriles as novel routes to 2-dialkylaminopyridines

3-Aroyl and 3-heteroaroyl substituted 3-oxoalkanenitriles were synthesized by the reactions of activated aromatic and hetero-aromatic substances with cyanoacetic acid in the presence of acetic anhydride. As part of studies focusing on the preparation of c

Studies with enaminones and enaminonitriles: synthesis of 3-aroyl and 3-heteroaroyl-pyrazolo-[1,5-a]pyrimidines

The reaction of electron rich aromatics with cyanoacetic acid and acetic anhydride afforded 3-oxoalkanenitriles. Indium trichloride was used as a Lewis acid catalyst when the aromatic ring was not?sufficiently reactive. The synthesized 3-oxoalkanenitriles were subsequently condensed with dimethylformamide dimethylacetal (DMFDMA) to yield enaminones that reacted readily with hydrazine hydrate to yield 4-aroylpyrazole-3-amines. The 4-aroylpyrazole-3-amines were condensed with enaminones to yield 3-aroylpyrazolo[1,5-a]pyrimidines.

3-(heteroarylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors

The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.