70988-04-4

Usage

Uses

Used in Pharmaceutical Industry:
3-(3',5'-DIMETHOXYPHENYL)-3-OXOPROPANENITRILE is used as a key intermediate in the synthesis of various pharmaceuticals for its potential biological activity, including antifungal and anti-inflammatory properties. It aids in the development of new therapeutic agents.
Used in Agrochemical Industry:
3-(3',5'-DIMETHOXYPHENYL)-3-OXOPROPANENITRILE is used as a building block in the creation of agrochemicals, leveraging its potential to contribute to the development of effective and novel compounds for agricultural applications.
Used in Organic Synthesis:
3-(3',5'-DIMETHOXYPHENYL)-3-OXOPROPANENITRILE is utilized as a synthetic building block for the preparation of a wide range of organic compounds, highlighting its versatility in chemical reactions and its potential to form complex molecular structures.

InChI:InChI=1/C11H11NO3/c1-14-9-5-8(11(13)3-4-12)6-10(7-9)15-2/h5-7H,3H2,1-2H3

Upstream product

• 1116-98-9 cyanoacetic acid tert-butyl ester 
• 20469-65-2 1-bromo-3,5-dimethoxybenzene 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 17275-82-0 ethyl 3,5-dimethoxybenzoate 
• 75-05-8 acetonitrile 

Downstream Products

• 569655-99-8 5-(3,5-dimethoxy-phenyl)-2H-pyrazol-3-ylamine 
• 1198105-26-8 3-(3,5-dimethoxyphenyl)propiolonitrile 
• 1152647-74-9 5-(3,5-dimethoxy-phenyl)-2-methyl-2H-pyrazol-3-ylamine 
• 1312949-29-3 ethyl 2-((3-(3,5-dimethoxyphenyl)-1,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)oxy)acetate 
• 1312949-28-2 3-(3,5-dimethoxyphenyl)-1,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one 
• 1312949-30-6 [3-(3,5-Dimethoxy-phenyl)-1,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yloxy]-acetic acid 
• 1312946-75-0 (S)-2-((3-(3,5-dimethoxyphenyl)-1,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)oxy)-N-(1-(4-methoxyphenyl)ethyl)acetamide 
• 179327-37-8 6-chloromethyl-4-(3,5-dimethoxy-phenyl)-2,3-dimethyl-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester 
• 179327-22-1 (2-amino-4,5-dimethyl-thiophen-3-yl)-(3,5-dimethoxy-phenyl)-methanone 

Relevant academic research and scientific papers

Palladium-Catalyzed Carbonylative α-Arylation of tert -Butyl Cyanoacetate with (Hetero)aryl Bromides

A three-component coupling protocol has been developed for the generation of 3-oxo-3-(hetero)arylpropanenitriles via a carbonylative palladium-catalyzed α-arylation of tert-butyl 2-cyanoacetates with (hetero)aryl bromides followed by an acid-mediated decarboxylation step. Through the combination of only a stoichiometric loading of carbon monoxide and mild basic reaction conditions such as MgCl2 and dicyclohexylmethylamine for the deprotonation step, an excellent functional group tolerance was ensured for the methodology. Through the use of 13C-labeled carbon monoxide generated from 13COgen, the corresponding 13C-isotopically labeled β-ketonitriles were obtained, and these products could subsequently be converted into cyanoalkynes and 3-cyanobenzofurans with site specific 13C-isotope labeling. (Chemical Equation Presented).

Design, synthesis, and evaluation of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines as novel PDE-4 inhibitors

Described herein is design, synthesis, and biological evaluation of novel series of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines acting as inhibitors of type 4 phosphodiesterase (PDE4) which is known as a good target for the treatment of asthma and COPD. For this purpose, structure optimization was conducted with the aid of structure-based drug design using the known X-ray crystallography. Also, biological effects of these compounds on the target enzyme were evaluated by using in vitro assays, leading to the potent and selective PDE-4 inhibitor (IC50 10 nM).