71001-78-0

Upstream product

• 63603-09-8 methyl 4-chloro-3-methoxy-5-nitrobenzoate 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 42590-00-1 4-hydroxy-3-methoxy-5-nitrobenzoic acid methyl ester 

Downstream Products

• 63603-16-7 2-chloro-3-nitro-5-bromoanisole 
• 63603-12-3 2-chloro-3-methoxy-5-bromoaniline 
• 71650-90-3 2-trimethylsilyl-ethyl N-methyl-(5-bromo-2-chloro-anisol-1-yl)-carbamat 
• 71653-15-1 2-chloro-3-[N-methyl-(2-trimethylsilyl-ethyl)-carbamato]-5-(5-bromo-2-methyl-(E,E)-2,4-pentadienyl)-anisole 
• 71650-89-0 (5-Bromo-2-chloro-3-methoxy-phenyl)-carbamic acid 2-trimethylsilanyl-ethyl ester 
• 71694-86-5 (5-Bromo-2-chloro-3-methoxy-phenyl)-carbamic acid phenyl ester 
• 86117-47-7 [({2-Chloro-5-[(2E,4E)-(6R,9S,10R)-9-(1-ethoxy-ethoxy)-7,7-bis-ethylsulfanyl-10-((2S,3R)-3-formyl-3-methyl-oxiranyl)-6-methoxy-2-methyl-undeca-2,4-dienyl]-3-methoxy-phenyl}-methyl-carbamoyl)-methyl]-phosphonic acid diethyl ester 
• 86116-97-4 C₄₅H₈₀ClNO₈S₂Si₂ 
• 86046-99-3 C₄₄H₇₈ClNO₈S₂Si₂ 
• 86046-99-3 C₄₄H₇₈ClNO₈S₂Si₂ 
• 52978-28-6 (-)-maysine 
• 72729-16-9 {(2S,3S)-3-[(6E,8E)-(1R,2S,5R)-10-(4-Chloro-3-methoxy-5-methylamino-phenyl)-2-(1-ethoxy-ethoxy)-4,4-bis-ethylsulfanyl-5-methoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol 
• 86117-46-6 (2R,3S)-3-[(6E,8E)-(1R,2S,5R)-10-(4-Chloro-3-methoxy-5-methylamino-phenyl)-2-(1-ethoxy-ethoxy)-4,4-bis-ethylsulfanyl-5-methoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxirane-2-carbaldehyde 
• 2137975-62-1 4-chloro-3-methoxy-5-nitrobenzamide 

Relevant academic research and scientific papers

2-(AZAINDOL-2-YL)BENZIMIDAZOLES AS PAD4 INHIBITORS

Compounds of formula (I): wherein; R1 is hydrogen or C1-6alkyl;R2 is hydrogen, C1-6alkyl, perhalomethylC0-5alkyl-O—, or C1-6alkoxy;R3 is hydrogen, C1-6alkyl, or C1-6alkoxyC1-6alkyl;R4 is hydrogen, C1-6alkyl, perhalomethylC1-6alkyl; or unsubstituted C3-6cycloalkylC1-6 alkyl;A is C—R5 or N;B is C—R6 or N;D is C—R7 or N;with the proviso that at least one of A, B, and D, is N;R5 is hydrogen or C1-6alkyl;R6 is hydrogen or C1-6alkyl;R7 is hydrogen, C1-6alkyl, C1-6alkoxy, or hydroxy;R8 is hydrogen or C1-6alkyl, with the proviso that one of R4 and R8 is hydrogen;R9 is hydrogen or hydroxy;R10 is hydrogen or C1-6alkyl; and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

2 - (AZAINDOL- 2 -YL) BENZ IMIDAZOLES AS PAD4 INHIBITORS

Compounds of formula (I) wherein; R1 is hydrogen or C1-6alkyl; R2 is hydrogen, C1-6alkyl, perhalomethylC0-5alkyl-O-, or C1-6alkoxy; R3 is hydrogen, C1-6alkyl, or C1-6alkoxyC1-6alkyl; R4 is hydrogen, C1-6alkyl, perhalomethylC1-6alkyl; or unsubstituted C3-6cycloalkylC1-6alkyl; A is C-R5 or N; B is C-R6 or N; D is C-R7 or N; with the proviso that at least one of A, B, and D, is N; R5 is hydrogen or C1-6alkyl; R6 is hydrogen or C1-6alkyl; R7 is hydrogen, C1-6alkyl, C1-6alkoxy, or hydroxy; R8 is hydrogen or C1-6alkyl, with the proviso that one of R4 and R8 is hydrogen; R9 is hydrogen or hydroxy; R10 is hydrogen or C1-6alkyl; and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

Total synthesis of (-)-maysine

A convergent synthesis of the natural macrocycle (-)-maysine (3) has been accomplished involving only a single separation of epimers at C-10. The scheme involved the preparation of three major fragments: (a) the western zone, 4; (b) the southern zone, 6;