71005-94-2

Upstream product

• 71005-92-0 1-ethyl-4-oxo-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide 
• 30720-04-8 1-ethyl-4-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 71005-93-1 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile 
• 52833-03-1 4-chloro-1-ethyl-1H-pyrazolo<3,4-b>pyridine-5-carbonyl chloride 

Relevant academic research and scientific papers

PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS

The invention relates to a compound of formula (I) or a salt thereof: wherein:R1 is C1-4alkyl, C1-3fluoroalkyl, -CH2CH2OH or -CH2CH2CO2C1-2alkyl;R2 is a hydrogen atom (H), methyl or C1fluoroalkyl;R3 is optionally substituted C3-8cycloalkyl or optionally substituted mono-unsaturated-C5-7cycloalkenyl or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc); in which n1 and n2 independently are 1 or 2; and in which Y is O, S, SO2, or NR10; or R3 is a bicyclic group (dd) or (ee): ; and wherein X is NR4R5 or OR5a. The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.

Hydrazino derivatives of 1H-pyrazolo(3,4-b)-pyridine-5-carboxamides

Hydrazino derivatives of 1H-pyrazolo[3,4-b]-pyridine-5-carboxamides which have the general formula STR1 are useful as ataractic agents, anti-allergy agents or anti-bronchoconstrictor agents.