710307-99-6Relevant academic research and scientific papers
Catalyst-free rapid synthesis of benzo[4,5]imidazo[1,2-a]-pyrimidine-3- carboxamides via four-component coupling in one pot
Shaabani, Ahmad,Seyyedhamzeh, Mozhdeh,Ganji, Nasim,Ng, Seik Weng
, p. 481 - 487 (2014/04/03)
Abstract: A new class of fused tricyclic benzo[4,5]imidazo[1,2-a]- pyrimidine-3-carboxamide derivatives was synthesized via an environmentally benign one pot sequential four-component condensation reaction of an amine, 2,2,6-trimethyl-4H-1,3-dioxin-4-one, an aldehyde and 1H-benzo[d]imidazol-2-amine without using catalyst in good yields.
Studies on log Po/w of quinoxaline di-N-oxides: A comparison of RP-HPLC experimental and predictive approaches
Moreno, Elsa,Gabano, Elisabetta,Torres, Enrique,Platts, James A.,Ravera, Mauro,Aldana, Ignacio,Monge, Antonio,Perez-Silanes, Silvia
scheme or table, p. 7893 - 7908 (2011/11/05)
As reported in our previous papers, a series of quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives were synthesized and studied as anti-tuberculosis agents. Here, the capability of the shake-flask method was studied and the retention time (expressed as log K) of 20 compounds were determined by RP-HPLC analysis. We found that the prediction of log P by the RP-HPLC analysis can result in a high accuracy and can replace the shake-flask method avoiding the experimental problems presented by quinoxaline di-N-oxides. The studied compounds were subjected to the ALOGPS module with the aim of comparing experimental log Po/w values and predicted data. Moreover, a preliminary in silico screening of the QSAR relationship was made confirming the influence of reduction peak potential, lipophilicity, H-bond donor capacity and molecular dimension descriptors on anti-tuberculosis activity.
Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives
Moreno, Elsa,Ancizu, Saioa,Pérez-Silanes, Silvia,Torres, Enrique,Aldana, Ignacio,Monge, Antonio
experimental part, p. 4418 - 4426 (2010/10/19)
As a continuation of our research and with the aim of obtaining new anti-tuberculosis agents which can improve the current chemotherapeutic anti-tuberculosis treatments, forty-three new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives were synthesized
