711014-68-5Relevant academic research and scientific papers
Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides
Marson, Charles M.,Serradji, Nawal,Rioja, Alphonso S.,Gastaud, Sebastien P.,Alao, John P.,Coombes, R. Charles,Vigushin, David M.
, p. 2477 - 2481 (2007/10/03)
Syntheses of (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides are described, some of which are potent inhibitors of histone deacetylase, a double bond conferring more than a 10-fold increase in potency compared with the triple bond analogue oxamflatin.
