7111-77-5

Basic information

• Product Name: 2'-Methyl-[1,1'-Biphenyl]-2-Carboxylic Acid
• Synonyms: [1,1'-Biphenyl]-2-carboxylic acid, 2'-methyl-;2'-methylbiphenyl-2-carboxylic acid(SALTDATA: FREE);2-(2-Methylphenyl)benzoic acid
• CAS NO: 7111-77-5
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.24
• Mol File: 7111-77-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 338.2 °C at 760 mmHg
• Flash Point: 159.2 °C
• Appearance: /
• Density: 1.156 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2'-Methyl-[1,1'-Biphenyl]-2-Carboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-Methyl-[1,1'-Biphenyl]-2-Carboxylic Acid(7111-77-5)
• EPA Substance Registry System: 2'-Methyl-[1,1'-Biphenyl]-2-Carboxylic Acid(7111-77-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-51
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 7111-77-5(Hazardous Substances Data)

Usage

Uses

2''-Methylbiphenyl-2-carboxylic Acid acts as a reagent in the preparation of orally active nonpeptide vasopressin V2 receptor antagonists, and also acts as an intermediate in varying organic synthetic processes.

Upstream product

• 131-62-4 1-hydroxy-1,2-benzodioxol-3-(1H)-one 
• 16419-60-6 2-Methylphenylboronic acid 
• 6091-64-1 2-bromobenzoic acid ethyl ester 
• 192637-88-0 2'-methylbiphenyl-2-carboxylic acid ethyl ester 
• 88-65-3 2-bromobenzoic-acid 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 579-75-9 2-Methoxybenzoic acid 
• 137600-70-5 2,6-di-tert-butyl-4-methylphenyl 2-methoxybenzoate 
• 137600-69-2 2,6-diisopropylphenyl 2-methoxybenzoate 
• 77408-43-6 2,4,6-trimethylphenyl 2-methoxybenzoate 
• 932-31-0 ortho-tolylmagnesium bromide 
• 95-46-5 2-methylphenyl bromide 

Downstream Products

• 484-17-3 9-Phenanthrol 
• 60848-13-7 N-methylphenanthren-9-amine 
• 7111-68-4 2'-methylbiphenyl-2-carboxaldehyde 
• 1859-10-5 4-methylfluoren-9-ol 
• 168162-74-1 methyl (Z)-[4,4-difluoro-1-[4-[2-(2-methylphenyl)benzoyl]amino]benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate 
• 183313-58-8 (2'-methylbiphenyl-2-yl)phenyldiazomethane 
• 183313-54-4 (2'-methylbiphenyl-2-yl)phenylmethanone hydrazone 
• 1059502-57-6 2-methyl-2'-[hydroxyl(phenyl)methyl]biphenyl 
• 168047-47-0 1-Ethoxycarbonylmethyl-5-{4-[2-(2-methylphenyl)benzoylamino]benzoyl}-1,3,4,5-tetrahydro-1,5-benzodiazepin-2(2H)-one 
• 168046-07-9 (5-{4-[(2'-methyl-biphenyl-2-carbonyl)-amino]-benzoyl}-2-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-acetic acid 

Relevant articles and documents

Annelated Pyridine Bases for the Selective Acylation of 1,2-Diols

A set of 24 annelated derivatives of 4-diaminopyridine (DMAP) has been synthesized and tested with respect to its catalytic potential in the regioselective acylation of 1,2-diol substrates. The Lewis basicities of the catalysts as quantified through quantum chemical calculations vary due to inductive substituent effects and intramolecular stacking interactions between side chain π-systems and the pyridinium core ring system. The primary over secondary hydroxyl group selectivities in catalytic acylations of 1,2-diol substrates depend on the size and the steric demand of the Lewis base and the anhydride reagent.

Exploration of Biaryl Carboxylic Acids as Proton Shuttles for the Selective Functionalization of Indole C-H Bonds

A survey of diversely substituted 2-arylbenzoic acids were synthesized and tested for use as proton shuttle in the direct arylation of indoles with bromobenzenes. It was found that 3-ethoxy-2-phenylbenzoic acid gives superior yield and selectivity for this class of substrates.

Electronic effects on the substitution reactions of benzhydrols and fluorenyl alcohols. Determination of mechanism and effects of antiaromaticity

A range of substituted benzhydrols and fluorenols were prepared and subjected to acid catalysed methanolysis. Analysis of the rates of each of these processes showed correlation with Hammett σ+ parameters as is consistent with the significant build-up of positive charge adjacent to the ring. In combination with the similarity of the electronic susceptibility of the processes, these data suggest that both reactions proceed through a unimolecular rate-determining step. This shows that the effect of fusion of the phenyl systems (and hence potentially introducing an antiaromatic carbocation intermediate) is only to slow the rate of reaction rather than change the mechanism of the process.