71118-02-0Relevant articles and documents
15β-hydroxysteroids (Part VII). Steroids of the human perinatal period: The synthesis of steroid markers and their radioactive tracers
Reeder, Anthony Y.,Joannou, George E.
, p. 221 - 225 (2007/10/03)
We report the synthesis of 10 novel steroids obtained from 3β,15β- diacetoxy-17α-hydroxy-5-pregnen-20-one (1c) as intermediates in the synthesis of 15β-acetoxy-20,20-ethylenedioxy-17α-hydroxy-4-pregnen-3-one (6a) and its tritiated tracer 15β-acetoxy-20-20-ethylenedioxy-17α-hydroxy- 1,2,6,7-3-pregn-4-en-3-one (6d). The one pot interconversion of intermediate (6a) to 3β,15β,17α-trihydroxy-5-pregnen-20-one (1a) and 3α,15β,17α- trihydroxy-5β-pregnan-20-one (2a) provides a new and efficient approach to the synthesis of diagnostically important metabolites of the human neonate and a possible route in the synthesis of the tritated tracers 3β,15β,17α- trihydroxy-1,2,7-3H-pregn-5-en-20-one (1d) and 3α,15β,17α-trihydroxy- 1,2,6,7-3H-5β-pregnan-20-one (2b) for the development of new immunoassays. We also report in this investigation an alternative route in the synthesis of 15β,17α-dihydroxy-4-pregnen-3,20-dione (7a) an intermediate in the synthesis of human 15β-hydroxysteroid metabolites.
Chick oviduct progesterone receptor binding of 15β,17-dihydroxyprogesterone and its analogues
Baker,McMorris,Terry,Barrow,Villanueva
, p. 153 - 158 (2007/10/02)
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