7112-00-7

Usage

Uses

Used in Pharmaceutical Applications:
2,4-dimethyl-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione is used as a potential therapeutic agent for its anti-inflammatory properties, which can help in managing inflammation-related conditions. Its anticancer properties are also being explored, indicating its potential to be developed into a treatment for various types of cancer.
Used in Antimicrobial Applications:
2,4-dimethyl-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione is utilized as an antimicrobial agent, leveraging its ability to combat microbial infections. It can be a valuable addition to the arsenal of antimicrobial substances, particularly in the context of increasing antibiotic resistance.
Used in Agricultural Applications:
2,4-dimethyl-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione is considered for use as a herbicide, where its potential to control the growth of unwanted plants could be beneficial in crop management and protection. This application is still under investigation, but the compound's properties suggest it could be a viable option for agricultural use.

Upstream product

• 6621-75-6 2,4-dimethylthiosemicarbazide 
• 85068-36-6 2,5-difluorobenzophenone 
• 4277-77-4 benzaldehyde-(2,4-dimethyl thiosemicarbazone) 
• 7112-01-8 1-benzoyl-2,4-dimethylthiosemicarbazide 
• 944-91-2 2,4-dimethyl-5-phenyl-2,4-dihydro-[1,2,4]triazol-3-one 
• 1663-61-2 triethoxymethylbenzene 
• 98-88-4 benzoyl chloride 
• 100994-59-0 5-(2,5-difluorophenyl)-2,4-dimethyl-5-phenyl-1,2,4-triazolidine-3-thione 
• 100994-58-9 2,5-difluorobenzophenone 2,4-dimethylthiosemicarbazone 

Relevant academic research and scientific papers

A Study of the Behaviour of 2,4-Substituted Thiosemicarbazides toward Orthoesters: Formation of Mesoionic Compounds

The reactions beetwen 2,4-disubstituted thiosemicarbazides and orthoesters in refluxing xylene led to the formation of the 1,2,4-triazoline-5-thione ring and to the 1,2,4-triazolium-5-thiolate ring. The formation of the mesoionic componds is due to rearrangement of the easily available 2,4-disubstituted thiosemicarbazides to 1,4-disubstituted thiosemicarbazides under the reaction conditions adopted. This method can be usefully used for the synthesis of mesoionic compounds, especially in the case of the 2-methyl-4-phenylthiosemicarbazide.

Substituent Effect on Oxidative Cyclization of Aldehyde Thiosemicarbazones with Ferric Chloride

The reactivity of aldehyde thiosemicarbazones 1 with ferric chloride solutions was examined.When compounds 1 are not substituted on the N-2 nitrogen atom formation of 1,3,4-thiadiazole 3 heterocyclic ring was observed.In contrast 1,2,4-triazoline 4 and/or

2,4-Dihydro-3H-1,2,4-triazole-3-thiones as Potential Antidepressant Agents

A series of 5-aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones was prepared and evaluated for potential antidepressant activity.Members of this series were generally prepared by the alkaline ring closures of the corresponding 1-aroylthiosemicarbazides.Several

Process for the preparation of 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones

This invention relates to a novel process for the preparation of 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3--thiones, useful as antidepressants, through the thionation of the corresponding 5-aryl-2,4-dialkyl-3H-1,2,4-triazol--3-ones.

The Bis(tricyclohexylstannyl) Sulfide Thionation of 3H-1,2,4-Triazol-3-ones

5-Aryl-2,4-dialkyl-2,4-dihydro-3H-1,2,4-triazol-3-ones may be converted in 55-74percent yield to the corresponding 3H-1,2,4-triazole-3-thiones by using the combination bis(tricyclohexylstannyl) sulfide/boron trichloride.