85068-36-6

Basic information

• Product Name: 2,5-DIFLUOROBENZOPHENONE
• Synonyms: Methanone, (2,5-difluorophenyl)phenyl-;2,5-DIFLUOROBENZOPHENONE;(2,5-DIFLUORO-PHENYL)-PHENYL-METHANONE;2,5-Difluorobenzophenone, 97+%;2,5-Difluorobenzophenone 97%;(2,5-Difluorophenyl)phenyl ketone
• CAS NO: 85068-36-6
• Molecular Formula: C₁₃H₈F₂O
• Molecular Weight: 218.2
• EINECS: 285-298-2
• Product Categories: Miscellaneous;Fluorine series
• Mol File: 85068-36-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 120 °C
• Flash Point: >110°C
• Appearance: /
• Density: 1.262
• Vapor Pressure: 0.000109mmHg at 25°C
• Refractive Index: 1.5693
• BRN: 4417185
• CAS DataBase Reference: 2,5-DIFLUOROBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIFLUOROBENZOPHENONE(85068-36-6)
• EPA Substance Registry System: 2,5-DIFLUOROBENZOPHENONE(85068-36-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 85068-36-6(Hazardous Substances Data)

Usage

Description

2,5-Difluorobenzophenone, a member of the benzophenone family, is a white crystalline solid with a molecular formula of C13H8F2O and a molecular weight of 220.2 g/mol. It is known for its unique chemical structure and properties, making it a valuable ingredient in the manufacturing of specialty chemicals, polymers, pharmaceuticals, perfumes, and other industrial products.

Uses

Used in Pharmaceutical Industry:
2,5-Difluorobenzophenone is used as an intermediate in the synthesis of various pharmaceuticals for its unique chemical properties that contribute to the development of new drugs.
Used in Perfume Industry:
2,5-Difluorobenzophenone is used as a building block in the creation of perfumes, leveraging its chemical structure to produce distinct and desirable fragrances.
Used in Industrial Applications:
2,5-Difluorobenzophenone is used as a photoinitiator in UV-curing applications, facilitating the curing process of various materials under ultraviolet light.
Used in Specialty Chemicals and Polymers Manufacturing:
2,5-Difluorobenzophenone is used as a key ingredient in the production of specialty chemicals and polymers, owing to its unique properties that enhance the performance of these materials.
Health Hazard Classification:
2,5-Difluorobenzophenone is classified as a low to moderate health hazard with mild skin and eye irritation potential, indicating the need for proper handling and safety measures during its use in various applications.

InChI:InChI=1/C13H8F2O/c14-10-6-7-12(15)11(8-10)13(16)9-4-2-1-3-5-9/h1-8H

Upstream product

• 408492-25-1 2-(2,5-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 100-52-7 benzaldehyde 
• 64248-64-2 2,5-difluorobenzonitrile 
• 80-17-1 benzenesufonyl hydrazide 
• 63468-90-6 phenylglyoxylic acid potassium salt 
• 201230-82-2 carbon monoxide 
• 211512-93-5 Trifluoro-methanesulfonic acid 2,5-difluoro-phenyl ester 
• 98-80-6 phenylboronic acid 
• 108-86-1 bromobenzene 
• 1421364-33-1 (2,5-difluorophenyl)diphenylmethanol 
• 119-61-9 benzophenone 
• 540-36-3 para-difluorobenzene 
• 98-88-4 benzoyl chloride 

Downstream Products

• 7112-00-7 2,4-dimethyl-5-phenyl-3H-1,2,4-triazole-3-thione 
• 342-59-6 5-fluoro-2-methoxybenzophenone 
• 100994-58-9 2,5-difluorobenzophenone 2,4-dimethylthiosemicarbazone 
• 100994-59-0 5-(2,5-difluorophenyl)-2,4-dimethyl-5-phenyl-1,2,4-triazolidine-3-thione 
• 57614-63-8 5-Fluoro-3-phenyl-1H-indazole 
• 88499-59-6 N₂-<(2,5-difluorophenyl)phenylmethylene>-N-methylhydrazinecarbothioamide 
• 1421364-33-1 (2,5-difluorophenyl)diphenylmethanol 
• 119-61-9 benzophenone 
• 1569280-41-6 C₁₉H₁₄FN₃O₂S 
• 1204771-72-1 C₁₇H₁₀FN₃O₂S 
• 300350-05-4 4-fluoro-2-benzoylthiophenol 
• 1220532-00-2 C₁₇H₁₂FNO₃ 
• 1227300-72-2 C₂₁H₁₂FN 
• 1606178-14-6 (4-fluoro-4'-methylbiphenyl-2-yl)(phenyl)methanone 

Relevant articles and documents

Photo-induced oxidative cleavage of C-C double bonds of olefins in water

The carbonyl compounds, synthesized by the oxidative cleavage of their corresponding olefins, are of great significance in organic synthesis, especially aryl ketones. We have developed a gentle and effective protocol, using acid red 94 as the organic metal-free photocatalyst, O2 as the oxidant, and water as the solvent. Under visible light irradiation, aryl ketone derivatives were obtained in moderate to excellent yields, showing good economic and environmental advantages.

Pd(II)-Catalyzed Denitrogenative and Desulfinative Addition of Arylsulfonyl Hydrazides with Nitriles

A Pd(II)-catalyzed denitrogenative and desulfinative addition of arylsulfonyl hydrazides with nitriles has been successfully achieved under mild conditions. This transformation is a new method for the addition reaction to nitriles with arylsulfonyl hydrazides as arylating agent, thus providing an alternative synthesis of aryl ketones. The reported addition reaction is tolerant to many common functional groups, and works well in the presence of electron-donating and electron-withdrawing substituents. Notably, the reported denitrogenative and desulfinative addition was also appropriate for alkyl nitriles, making this newly developed transformation attractive.

Method for preparing aromatic ketone in aqueous phase

The invention discloses a method for preparing aromatic ketone in an aqueous phase, comprising the following steps: enabling aryl formyl potassium formate and aryl potassium fluoborate to generate decarboxylation acylation reaction in water under the actions of a silver catalyst and an oxidizing agent, and performing treatment after reaction is ended to obtain the disclosed aromatic ketone. According to the preparation method, the silver catalyst replaces a noble metal catalyst, water is taken as a solvent, an aromatic ketone product is obtained with relatively high yield, the adopted catalystis low in cost and easy to obtain, reaction conditions are mild, and meanwhile, the product is good in university, and therefore, the method has good application potential.