93619-74-0Relevant academic research and scientific papers
Synthesis of Neu5Ac-α-C-galactopyranosyl-functionalized magnetic nanoparticles via click chemistry
Zhang, Chaoli,Ma, Xing,Du, Yuguo
, p. 7300 - 7307 (2013/08/23)
A new type of glyco-nanoparticle has been accomplished through Cu(I)-catalyzed 1,3-dipolar cycloaddition of 6-azidohexyl Neu5Ac-α-C- galactoside and N-propargyl derivative, which was attached on a silica-wrapping magnetic nanoparticle. Neu5Ac-α-C-galactos
Solution- and solid-phase synthesis of inhibitors of H. pylori attachment and E-selectin-mediated leukocyte adhesion
Halcomb,Huang,Wong
, p. 11315 - 11322 (2007/10/02)
Chemical and enzymatic methods have been developed for the synthesis of the oligosaccharides NeuAcα2 → 3Galβ1 → 4GlcNAcβ1 → 3Gal and NeuAcα2 → 3Galβ1 → 4(Fucα1 → 3)GlcNAcβ1 → 3Gal as inhibitors for H. pylori and E-selectin, respectively. Gal, NeuAc, and Fuc were incorporated sequentially into the synthetic primer GlcNAcβ1 → 3GalβOEt by the corresponding glycosyltransferases to give both the tetrasaccharide and the pentasaccharide. This solution-phase strategy was then extended to the solid-phase synthesis of the tetrasaccharide. A disaccharide primer was first attached to controlled pore glass via a spacer group containing an ester bond, followed by enzymatic incorporation of Gal and NeuAc. Two to three equivalents of sugar nucleotides were used in the enzymatic glycosylation, and the conversion for each step was found to be >98% as indicated in the analysis of products released by treatment with hydrazine.
Preparation of 3-Methoxycarbonylpropyl α-D- and 7-Methoxycarbonylhexyl β-D-Galactopyranosides: Spacer-arm Glycosides for Branched Oligosaccharide Synthesis
Collins, Peter M.,Eder, Hansjoerg
, p. 1525 - 1530 (2007/10/02)
7-Methoxycarbonylheptyl β-D-galactopyranoside (7), 3-methoxycarbonylpropyl α-D-galactopyranoside (18), and its 6-O-pivaloloyl derivative (20), suitable for coupling to proteins or functionalised solid supports, have been synthesised from galactopyranosylo
