7113-05-5

Upstream product

• 857550-21-1 2-phenyl-1,3-thiazole-4-carboxamide 
• 108735-87-1 2-phenyl-4-formyl-thiazole oxime 
• 20949-81-9 2-phenyl-thiazole-4-carbaldehyde 
• 7113-10-2 2-phenyl-1,3-thiazole-4-carboxylic acid 
• 2227-79-4 benzenecarbothioamide 
• 59937-01-8 2-phenylthiazole-4-carboxylic acid ethyl ester 

Downstream Products

• 7113-10-2 2-phenyl-1,3-thiazole-4-carboxylic acid 
• 21917-81-7 3-phenyl-8-oxo-5,6,7,8-tetrahydro-thiazolo[3,4-a]pyridinylium; bromide 
• 21917-82-8 8-acetoxy-3-phenyl-5,6-dihydro-thiazolo[3,4-a]pyridinylium; bromide 
• 7113-02-2 2-phenyl-1,3-thiazole-4-carboxylic acid methyl ester 
• 65823-57-6 4-(4-chloro-phenyl)-2'-phenyl-[2,4']bithiazolyl 
• 1569318-98-4 C₁₉H₁₃N₃O₂S₂ 
• 1416716-40-9 2-phenyl-4-(1H-tetrazol-5-yl)thiazole 
• 10477-28-8 4,2'-diphenyl-[2,4']bithiazolyl 
• 7113-14-6 2-phenylthiazole-4-carbothioamide 
• 94487-81-7 N-hydroxy-2-phenyl-thiazole-4-carboximidic acid amide 
• 21917-78-2 4-ethoxy-1-(2-phenyl-thiazol-4-yl)-butan-1-one 

Relevant academic research and scientific papers

Efficient nitriding reagent and application thereof

The invention discloses an efficient nitriding reagent and application thereof, wherein the nitriding reagent comprises nitrogen oxide, an active agent, a reducing agent and an organic solvent. By applying the nitriding reagent, nitrogen-containing compounds such as amide, nitrile and the like can be produced, and the method is simple in condition, low in waste discharge amount and simple in reaction equipment.

Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles

The Schmidt reaction has been an efficient and widely used synthetic approach to amides and nitriles since its discovery in 1923. However, its application often entails the use of volatile, potentially explosive, and highly toxic azide reagents. Here, we report a sequence whereby triflic anhydride and formic and acetic acids activate the bulk chemical nitromethane to serve as a nitrogen donor in place of azides in Schmidt-like reactions. This protocol further expands the substrate scope to alkynes and simple alkyl benzenes for the preparation of amides and nitriles.

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

Synthesis, Characterization, and Antimicrobial Screening of 4″-methyl-2,2″-diaryl-4,2′:4′,5″-terthiazole Derivatives

A series of novel 4″-methyl-2,2″-diaryl-4,2′:4′,5″-terthiazole (8a-p) derivatives has been synthesized and screened for antibacterial activity against four pathogenic bacteria, Escherichia coli, Pseudomonas flurescence, Staphylococcus aureus, and Bacillus subtilis. Among them, compounds 8a and 8j exhibited excellent antibacterial activity with minimum inhibitory concentration range of 1.0 to 5.3?μg/mL and compounds 8m and 8p exhibited moderate to good antibacterial activity with minimum inhibitory concentration range of 16.9 to 29.7?μg/mL against all tested strains. All the synthesized compounds were screened for their in vitro antifungal activity against Cocinida candida. Most of the compounds reported moderate antifungal activity. This study provides valuable directions to our ongoing endeavor of rationally designing more potent antimicrobial agent.

The effect of some 4,2 and 5,2 bisthiazole derivatives on nitro-oxidative stress and phagocytosis in acute experimental inflammation

Nineteen bisthiazoles were tested in order to assess their anti-inflammatory and antioxidant properties. First, we evaluated the in vitro direct antioxidant capacity of the bisthiazoles using the DPPH radical scavenging method. Then, the anti-inflammatory

Docking, synthesis, and pharmacological investigation of novel substituted thiazole derivatives as non-carboxylic, anti-inflammatory, and analgesic agents

A series of substituted thiazole derivatives (6-16) were synthesized to obtain new compounds with potential anti-inflammatory and analgesic activities. At equimolar oral doses, compounds 3-(piperidin-1-yl-methyl)-1, 3, 4-oxadiazol-2-thione (14), 5-amino-4

N-PHENYLAMIDINES AS 5-HT2A RECEPTOR ANTAGONISTS

Compounds of formula (I), are 5-HT2A receptor antagonists, and hence find use in treatment of a variety of adverse conditions of the 10 central nervous system.

Hantzsch reaction intermediates as a means to obtain bisthiazoles and 5-acetyl-bisthiazoles

The synthesis, chemical and spectral data of some intermediates of Hantzsch's reaction is described. The synthesis of some 4-R-5-R1-2'-Aryl-2,4'-bisthiazoles was presented too. By interaction of acetic anhydride, hydroxythiasoline derivatives were converted to 5-acetyl-bisthiazoles.