7114-76-3Relevant articles and documents
OXYDATION DES TETRALONES PAR LE SUPEROXYDE DE POTASSIUM SOLUBILISE PAR ETHER-COURONNE
Hocquaux, Michel,Jacquet, Bernard,Vidril-Robert, Daniele,Maurette, Marie-Therese,Oliveros, Esther
, p. 533 - 536 (1984)
α and β-tetralones are oxidised in tetrahydrofuran solution by means of potassium superoxide with crown-ether to give 2-hydroxy-1,4 naphtoquinone with fair to good yields.
Iridium-Catalyzed Cycloisomerization of Alkynoic Acids: Synthesis of Unsaturated Lactones
Huang, Yi,Zhang, Xianghe,Dong, Xiu-Qin,Zhang, Xumu
, p. 782 - 788 (2020/01/08)
The iridium-catalyzed cycloisomerization of various alkynoic acids was successfully developed, and a series of five-, six-, and especially seven-membered unsaturated lactones were constructed with moderate yields and excellent regioselectivities (up to 68
Benzoyl 2-methyl indoles as selective PPARγ modulators
Acton III, John J.,Black, Regina M.,Jones, A. Brian,Moller, David E.,Colwell, Lawrence,Doebber, Thomas W.,MacNaul, Karen L.,Berger, Joel,Wood, Harold B.
, p. 357 - 362 (2007/10/03)
A series of selective PPARγ modulators (SPPARγMs) and their development from hPPARγ active screening leads 1 and 2 is described. SPPARγM 24 displayed robust anti-diabetic activity with an improved therapeutic window in comparison to a PPARγ full agonist in a rodent efficacy model. Routine screening for human PPAR ligands yielded compounds 1 and 2, both of which were sub-micromolar hPPARγ agonists. Synthetic modifications of these leads led to a series of potent substituted 3-benzyl-2-methyl indoles, a subset of which were noted to be selective PPARγ modulators (SPPARγMs). SPPARγM 24 displayed robust anti-diabetic activity with an improved therapeutic window in comparison to a PPARγ full agonist in a rodent efficacy model.
