71214-33-0

Usage

Uses

Used in Pharmaceutical Industry:
(1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-ribo-hexopyranoside hydrochloride (1:1) is used as an antimicrobial agent for its ability to target and combat various microbial infections. The tetracycline backbone of the compound contributes to its broad-spectrum antimicrobial activity, making it a promising candidate for treating a range of bacterial infections.
Additionally, the hydrochloride salt form of the compound may be utilized to improve the solubility and stability of the drug, facilitating its formulation and administration in various pharmaceutical dosage forms. This could enhance the compound's bioavailability and therapeutic efficacy, making it a valuable asset in the development of new antimicrobial and anticancer drugs.

Upstream product

• 21794-55-8 (+)-Daunomycinone 
• 108-24-7 acetic anhydride 
• 76753-25-8 2,3,6-tridesoxy-4-O-p-nitrobenzoyl-3-trifluoroacetamido-D-lyxo-hexopyranose 
• 76753-28-1 methyl-2,3,6-tridesoxy-4-O-p-nitrobenzoyl-3-trifluoroacetamido-α-D-lyxo-hexopyranoside 
• 76793-39-0 methyl-2,3,6-tridesoxy-3-trifluoroacetamido-α-D-lyxo-hexopyranoside 
• 76793-38-9 methyl-3-amino-2,3,6-tridesoxy-α-D-lyxo-hexopyranoside 
• 6605-27-2 methyl-3-acetamido-2,3,6-tridesoxy-α-D-lyxo-hexopyranoside 

Relevant academic research and scientific papers

HEMISYNTHESE DE NOUVEAUX GLICOSIDES ANALOGUES DE LA DAUNORUBICINE

Seven daunorubicin analogs containing α-L-, α-D-, and β-D-glicosidic linkages, in which the natural occuring sugar (L-daunosamine) was replaced by diastereomeric 3-amino-2,3,6-trideoxyhexoses (3-epi-L-daunosamine, D-acosamine, D-daunosamine, D-ristosamine, and 3-epi-D-daunosamine), were prepared.In all cases, glycosidation with daunomycinone was performed in the presence of p-toluenesulfonic acid starting from 1-O-acetyl-2,3,6-trideoxy-4-O-p-nitrobenzoyl-3-trifluoro-acetamidohexopyranoses (prepared from the corresponding methyl 3-amino-2,3,6-trideoxyhexopyranosides) or from 1,5-anhydro-2,3,6-trideoxy-4-O-p-nitrobenzoyl-3-trifluoroacetamidohex-1-enitols (prepared from glycosals or pseudoglycals, the 3-amino group being introduced by substitution with sodium azide and subsequent reduction).Glycosidation was followed by removal of the protecting groups.