712273-24-0

Upstream product

• 712273-32-0 N-methoxy-N-methyl-4-(2-phenylsulfanyl-1H-indol-3-yl)-butyramide 
• 712273-25-1 5-(2-phenylsulfinyl-1H-indol-3-yl)-pentan-2-one 
• 712273-35-3 5-(2-phenylsulfanyl-1H-indol-3-yl)-pentan-2-one 
• 145912-72-7 3-((4'-N,O-dimethyl hydroxyamido)-butan)-indole 
• 133-32-4 4-indol-3-yl-butyric acid 
• 712273-23-9 2-benzenesulfinyl-3-(4-triisopropylsilanyloxy-pent-4-enyl)-1H-indole 
• 863976-69-6 2-phenylsulfenyl-3-(4-triisopropylsilanyloxy-pent-4-enyl)-1H-indole 

Relevant academic research and scientific papers

Extending Pummerer reaction chemistry. Application to the oxidative cyclization of indole derivatives

Matrix presented. Treatment of 2-(phenylsulfinyl)indoles bearing a pendant nucleophile at C(3) with Tf2O/lutidine triggers a Pummerer-like cyclization to furnish 3,3-spirocyclic-2-(phenylthio)indolenine products, which can, in turn, be hydrolyzed to 3,3-spirocyclic oxindoles.

Use of Stang's reagent, PhI(CN)OTf, to promote Pummerer-like oxidative cyclization of 2-(phenylthio)indoles

Treatment of various 2-(phenylthio)indoles, bearing nucleophilic groups tethered to C(3), with PhI(CN)OTf initiated an oxidative cyclization sequence that afforded 3,3-spirocyclic 2-(phenylthio)indolenines or oxindoles in moderate yield.