712344-28-0

Basic information

• Product Name: N-(2-methoxyphenyl)-2-(4-nitrobenzamido)benzamide
• Synonyms: N-(2-methoxyphenyl)-2-(4-nitrobenzamido)benzamide
• CAS NO: 712344-28-0
• Molecular Weight: 391.383
• Mol File: 712344-28-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-methoxyphenyl)-2-(4-nitrobenzamido)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methoxyphenyl)-2-(4-nitrobenzamido)benzamide(712344-28-0)
• EPA Substance Registry System: N-(2-methoxyphenyl)-2-(4-nitrobenzamido)benzamide(712344-28-0)

Safety Data

• Hazardous Substances Data: 712344-28-0(Hazardous Substances Data)

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 70083-21-5 2-amino-N-(2-methoxyphenyl)benzamide 
• 90-04-0 2-methoxy-phenylamine 
• 17296-34-3 N-(2-methoxyphenyl)-2-nitrobenzamide 
• 552-16-9 ortho-nitrobenzoic acid 

Relevant articles and documents

SAR and lead optimization of an HIV-1 Vif-APOBEC3G axis inhibitor

We describe structure-activity relationship and optimization studies of RN-18, an HIV-1 Vif-APOBEC3G axis inhibitor. Targeted modifications of RN-18 ring C, ring B, ring A, bridge A-B, and bridge B-C were performed to identify the crucial structural features, which generated new inhibitors with similar (4g and 4i) and improved (5, 8b, and 11) activities. Two potent water-soluble RN-18 analogues, 17 and 19, are also disclosed, and we describe the results of pharmacological studies with compound 19. The findings described here will be useful in the development of more potent Vif inhibitors and in the design of probes to identify the target protein of RN-18 and its analogues.