70083-21-5

Basic information

• Product Name: 2-AMINO-N-(2-METHOXY-PHENYL)-BENZAMIDE
• Synonyms: 2-AMINO-N-(2-METHOXY-PHENYL)-BENZAMIDE
• CAS NO: 70083-21-5
• Molecular Formula: C₁₄H₁₄N₂O₂
• Molecular Weight: 242.27
• Mol File: 70083-21-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 346.3 °C at 760 mmHg
• Flash Point: 163.2 °C
• Appearance: /
• Density: 1.245 g/cm³
• Vapor Pressure: 5.82E-05mmHg at 25°C
• Refractive Index: 1.658
• CAS DataBase Reference: 2-AMINO-N-(2-METHOXY-PHENYL)-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-(2-METHOXY-PHENYL)-BENZAMIDE(70083-21-5)
• EPA Substance Registry System: 2-AMINO-N-(2-METHOXY-PHENYL)-BENZAMIDE(70083-21-5)

Safety Data

• Hazardous Substances Data: 70083-21-5(Hazardous Substances Data)

Usage

General Description

2-AMINO-N-(2-METHOXY-PHENYL)-BENZAMIDE is a synthetic chemical compound with the molecular formula C14H14N2O2. It is an amide derivative with a benzene ring and an amino group. 2-AMINO-N-(2-METHOXY-PHENYL)-BENZAMIDE is also known as 2-(2-Aminophenyl)-N-(2-methoxyphenyl)benzamide and is mainly used in organic synthesis and pharmaceutical research. It has potential applications in medicinal chemistry and drug development due to its structural features and pharmacological properties. This chemical has been studied for its potential use in the treatment of various medical conditions, and it has shown promise in preclinical research. Its precise mechanism of action and specific therapeutic uses have yet to be fully elucidated.

InChI:InChI=1/C14H14N2O2/c1-18-13-9-5-4-8-12(13)16-14(17)10-6-2-3-7-11(10)15/h2-9H,15H2,1H3,(H,16,17)

Upstream product

• 552-16-9 ortho-nitrobenzoic acid 
• 17296-34-3 N-(2-methoxyphenyl)-2-nitrobenzamide 
• 90-04-0 2-methoxy-phenylamine 
• 118-92-3 anthranilic acid 
• 21563-73-5 2-aminobenzoyl chloride 
• 118-48-9 isatoic anhydride 

Downstream Products

• 1379465-08-3 N-(2-methoxyphenyl)-2-(3-(4-nitrophenyl)ureido)benzamide 
• 712344-28-0 N-(2-methoxyphenyl)-2-(4-nitrobenzamido)benzamide 
• 37856-18-1 3-(2-methoxyphenyl)-2-phenylquinazolin-4(3H)-one 
• 4260-28-0 2-methyl-3-(o-methoxyphenyl)-4(3H)-quinazolinone 
• 3977-52-4 3-(2-methoxyphenyl)-4(3H)-quinazolinone 
• 107559-07-9 3-(2-methoxyphenyl)benzo[d][1,2,3]triazin-4(3H)-one 
• 1013275-87-0 N-(2-methoxyphenyl)-2-(4-nitrophenylsulfonamido)benzamide 
• 1263153-05-4 C₁₈H₁₈N₂O₅ 
• 1263153-06-5 ethyl 3-(o-methoxyphenyl)-4-oxo-3,4-dihydroquinazoline-2-carboxylate 
• 127662-29-7 3-(2-methoxy-phenyl)-1,2,3,4-tetrahydro-quinazoline 
• 133040-60-5 2-[2-(1H-Indol-3-yl)-ethyl]-3-(2-methoxy-phenyl)-3H-quinazolin-4-one 

Relevant articles and documents

Sustainable methine sources for the synthesis of heterocycles under metal- and peroxide-free conditions

Alcohols and ethers were identified as sustainable methine sources for synthesizing quinazolinone and benzimidazole derivatives using a combination of TsOH·H2O/O2 and appropriate bis-nucleophiles for the first time. Deuterium labeling studies clearly proved that the C2 hydrogen of the synthesized heterocycles came from the methine source. These unique reaction conditions were successfully applied to the synthesis of echinozolinone (2e′), 2f′ (a common precursor of rutaecarpine and (±) evodiamine), and dimedazole (6d). Notable features of this method include its low toxicity, use of commercial feedstocks as substrates, low cost, broad functional group tolerance and suitability for a wide range of bis-nucleophilic starting materials.

One-Pot, Multistep Reactions for the Modular Synthesis of N, N′-Diarylindazol-3-ones

The pot-economic synthesis of N,N′-diarylindazol-3-ones has been developed using readily available isatoic anhydrides, aryl amines, and aryl boronic acids. A Cu-catalyzed oxidative C-N cross-coupling and dehydrogenative N-N formation sequence under an air atmosphere affords indazol-3-one derivatives in good to excellent yields. Such process merges well with the preceding decarboxylative amination reaction, resulting in a more modular and straightforward approach.

Discovery and characterization of 2-(cyclopropanesulfonamido)-n-(2-ethoxyphenyl)benzamide, ML382: A potent and selective positive allosteric modulator of MrgX1

Previous studies have shown that the activation of mouse MrgC11, a G-protein-coupled receptor, by its peptide ligand BAM8-22 can inhibit chronic pain. A large-scale screen has been carried out to isolate small-molecule allosteric agonists of MrgX1, the human homologue of MrgC11. The goal of this study is to improve the efficacy and potency of positive allosteric modulators (PAMs) with therapeutic implications in combating chronic pain. Herein we report an iterative parallel synthesis effort and a structure-activity relationship study of a series of arylsulfonamides which led to the discovery of the first PAM of MrgX1, ML382.