112758-89-1

Basic information

• Product Name: tert-butyl2-(piperazin-1-yl)ethylcarbamate
• Synonyms: 1-Phenyl-1,2,3,4-Tetrahydropyr;1-phenyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine(SALTDATA: FREE);1-phenyl-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine;1,2,3,4-Tetrahydro-1-phenylpyrrolo[1,2-a]pyrazine
• CAS NO: 112758-89-1
• Molecular Formula: C₁₃H₁₄N₂
• Molecular Weight: 229.31922
• Mol File: 112758-89-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 73-74 °C
• Boiling Point: 343°C at 760 mmHg
• Flash Point: 161.2°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 7.26E-05mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: 2-8°C
• PKA: 6.65±0.40(Predicted)
• CAS DataBase Reference: tert-butyl2-(piperazin-1-yl)ethylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl2-(piperazin-1-yl)ethylcarbamate(112758-89-1)
• EPA Substance Registry System: tert-butyl2-(piperazin-1-yl)ethylcarbamate(112758-89-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 112758-89-1(Hazardous Substances Data)

Usage

General Description

Tert-butyl2-(piperazin-1-yl)ethylcarbamate, also known as N-tert-butyl-2-(1-piperazinyl)ethylcarbamate, is a chemical compound with the molecular formula C12H24N4O2. It is a white crystalline solid with a molecular weight of 252.35 g/mol. tert-butyl2-(piperazin-1-yl)ethylcarbamate is commonly used as a pharmaceutical intermediate in the synthesis of various drugs, including antihistamines and antimicrobial agents. It exhibits a wide range of pharmacological activities, including antiviral, antitumor, and anti-inflammatory properties. Tert-butyl2-(piperazin-1-yl)ethylcarbamate is also used as a research chemical and as a building block in organic synthesis. However, it is important to handle and use this compound with caution, as it may pose health hazards if not properly handled.

InChI:InChI=1/C13H14N2/c1-2-5-11(6-3-1)13-12-7-4-9-15(12)10-8-14-13/h1-7,9,13-14H,8,10H2

Upstream product

• 108-86-1 bromobenzene 
• 71257-37-9 3,4-dihydropyrrolo[1,2-a]-pyrazine 
• 136927-87-2 1-(2-(N-benzoylamino)ethyl)pyrrole 
• 98-88-4 benzoyl chloride 
• 29709-35-1 1-(2-aminoethyl)pyrrole 
• 100-52-7 benzaldehyde 
• 71257-38-0 1,2,3,4-Tetrahydropyrrolo<1,2-a>pyrazine 
• 111609-55-3 1-phenyl-3,4-dihydropyrrolo<1,2-a>pyrazine 

Downstream Products

• 155206-41-0 1-cyclohexyloctahydropyrrolo<1,2-a>pyrazine 
• 1020656-54-5 tert-butyl 2-oxo-2-(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethylcarbamate 
• 1020656-18-1 4-oxo-4-(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)butanoic acid 
• 1020656-67-0 3-oxo-3-(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)propanoic acid methyl ester 
• 1185503-53-0 C₃₁H₃₂F₃N₅O 
• 1174283-09-0 N-(2-(2-(1-tert-butyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-N,2,4,6-tetramethylbenzenesulfonamide 
• 1174282-70-2 4-methoxy-N,2,3,6-tetramethyl-N-(2-(2-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)benzenesulfonamide 
• 1174283-11-4 N,2,4,6-tetramethyl-N-(2-(2-oxo-2-(1-(pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethoxy)ethyl)benzenesulfonamide 
• 1174282-63-3 N-(2-(2-(5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-oxoethoxy)ethyl)-N-isobutyl-4-methoxy-2,3,6-trimethylbenzenesulfonamide 
• 1174282-88-2 N-benzyl-4-methoxy-2,6-dimethyl-N-(2-(2-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)benzenesulfonamide 
• 1174283-17-0 N-(2-(2-(1-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-N,2,4,6-tetramethylbenzenesulfonamide 
• 1174282-82-6 N-benzyl-4-methoxy-2,3,6-trimethyl-N-(2-(2-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)benzenesulfonamide 
• 1174283-06-7 4-methoxy-N-(2-(2-(1-(3-methoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-N,2,6-trimethylbenzenesulfonamide 
• 1174282-85-9 N-benzyl-N-(2-(2-(5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-oxoethoxy)ethyl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide 

Relevant articles and documents

A Robust, Recyclable Resin for Decagram Scale Resolution of (±)-Mefloquine and Other Chiral N-Heterocycles

Decagram quantities of enantiopure (+)-mefloquine have been produced via kinetic resolution of racemic mefloquine using a ROMP-gel supported chiral acyl hydroxamic acid resolving agent. The requisite monomer was prepared in a few synthetic steps without chromatography and polymerization was safely performed on a >30 gram scale under ambient conditions. The reagent was readily regenerated and reused multiple times for the resolution of 150 grams of (±)-mefloquine and other chiral N-heterocylces.

Substituted Sulfonamide Compounds

Substituted sulfonamide compounds corresponding to the formula I wherein m, n, p, Q, R1, R2, R3, R4, X, Y and Z have the respective meanings defined herein, pharmaceutical compositions containing such compounds, a process for their preparation, and the use of such compounds for the treatment and/or inhibition of pain and other conditions mediated by bradykinin receptor 1 (B1R) and/or bradykinin receptor 2 (B2R).

Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in the Treatment and/or Inhibition of Pain

Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K+ channels.