71270-61-6

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 95-74-9 3-chloro-p-toluidine 
• 4284-47-3 N-(4-methylphenyl)methanesulfonamide 

Downstream Products

• 71270-36-5 2-[(3-Chloro-4-methyl-phenyl)-methanesulfonyl-amino]-thioacetamide 
• 162100-42-7 6-chloro-5-methyl-1H-indole 
• 162100-44-9 6-chloro-5-methyl-2,3-dihydro-1H-indole 

Relevant academic research and scientific papers

Direct C-H substitution reaction of anilides using hypervalent iodine and their regioselective issues

The direct C-H substitution reactions of anilides using hypervalent iodine proceeded to afford azide, chloro, bromo, and fluoro derivatives, and their regioselectivity were described. In the specific reaction conditions, the unique regioisomers were obtai

Novel and selective 5-HT(2C/2B) receptor antagonists as potential anxiolytic agents: Synthesis, quantitative structure - Activity relationships, and molecular modeling of substituted 1-(3- pyridylcarbamoyl)indolines

The synthesis, biological activity, and molecular modeling of a novel series of substituted 1-(3-pyridylcarbamoyl)indolines are reported. These compounds are isosteres of the previously published indole urea 1 (SB- 206553) and illustrate the use of aromatic disubstitution as a replacement for fused five-membered rings in the context of 5-HT(2C/2B) receptor antagonists. By targeting a region of space previously identified as sterically allowed at the 5-HT(2C) receptor but disallowed at the 5-HT(2A) receptor, we have identified a number of compounds which are the most potent and selective 5-HT(2C/2B) receptor antagonists yet reported. 46 (SB-221284) was selected on the basis of its overall biological profile for further evaluation as a novel, potential nonsedating anxiolytic agent. A CoMFA analysis of these compounds produced a model with good predictive value and in addition good qualitative agreement with both our 5-HT(2C) receptor model and our proposed binding mode for this class of ligands within that model.