71294-64-9Relevant articles and documents
Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction
Galman, James L.,Slabu, Iustina,Parmeggiani, Fabio,Turner, Nicholas J.
supporting information, p. 11316 - 11319 (2018/10/24)
Heterocycles based on piperidine and pyrrolidine are key moieties in natural products and pharmaceutically active molecules. A novel multi-enzymatic approach based on the combination of a lipase with an α,ω-diamine transaminase is reported, opening up the synthesis, isolation and characterisation of a broad range of 2-substituted N-heterocycle alkaloids.
SYNTHESIS OF THE ALKALOIDS JULANDINE AND IPALBIDINE - USE OF SILICON (IV) CHLORIDE
Cragg, John E.,Hedges, Stuart H.,Herbert, Richard B.
, p. 2127 - 2130 (2007/10/02)
Titanium (IV) chloride and silicon (IV) chloride with high oxygen affinity are the best Lewis acid catalysts, of a number tested, for cyclisation of an enamine-ketone (1) leading to the alkaloid, julandine (2); cyclisation of (6) in methanol solution without catalyst yields O-methylipalbidine (7).