71302-20-0Relevant academic research and scientific papers
Enantioselective radical methods for lactone synthesis: Use of unprotected haloalcohols as radical precursors
Sibi, Mukund P.,Guerrero, Miguel A.
, p. 1528 - 1532 (2007/10/03)
We have developed an efficient free radical method for the synthesis of enantioenriched 6- and 7-membered lactones in one synthetic operation. Georg Thieme Verlag Stuttgart.
Catalytic enantioselective conjugate reduction of lactones and lactams
Hughes, Gregory,Kimura, Masanari,Buchwald, Stephen L.
, p. 11253 - 11258 (2007/10/03)
A dramatic acceleration of the enantioselective copper-catalyzed conjugate reduction of α,β-unsaturated lactones, lactams, and esters is reported upon addition of alcohol additives. Good to excellent yields and enantioselectivities were realized using a catalyst generated in situ from CuCl2·H2O, t-BuONa, p-tol-BINAP, and PMHS, and this methodology was applied to the synthesis of (-)-Paroxetine.
Preparations of Chiral δ-Lactones via Enantiotopically Specific Pig Liver Esterase-catalysed Hydrolyses of 3-Substituted Glutaric Acid Diesters
Francis, Christopher J.,Jones, J. Bryan
, p. 579 - 580 (2007/10/02)
Pig liver esterase-catalysed hydrolyses of 3-monosubstituted glutaric acid diesters are pro-S enantiotopically specific for a broad range of C-3 substituents and permit either enantiomer of the corresponding 3-substituted valerolactones of 100percent e.e.
