713086-44-3

Upstream product

• 10604-59-8 N-Ethylindole 
• 201230-82-2 carbon monoxide 
• 98-80-6 phenylboronic acid 
• 13141-38-3 2-phenylethynylaniline 
• 93-58-3 benzoic acid methyl ester 
• 67-66-3 chloroform 
• 536-74-3 phenylacetylene 
• 615-43-0 2-iodophenylamine 
• 1864-94-4 phenyl formate 
• 95-20-5 2-methyl-1H-indole 
• 611-73-4 Benzoylformic acid 
• 1218812-68-0 N-ethyl-N-methyl-2-(phenylethynyl)aniline 

Relevant academic research and scientific papers

Rapid access to 3-acyl indoles using ethyl acetate/triflic acid couple as the acylium donor and Cu(OAc)2catalysed aerial oxidation of indole benzoins

Esters are potential acyl donors but are relatively unexplored for that purpose. A facile installation of acyl groups at the C-3 position of indoles under triflic acid catalysed conditions with easily available and cheap esters as new acylating agents is described herein. Furthermore, heterocycles like N-protected pyrrole, furan and thiophene were also suitable substrates for similar C-2 acylation. Analogous C-3 benzoylated products of indole were obtained, albeit in lower yields, by using methyl benzoate as a benzoyl donor. The benzoylated products were synthesised in much better yields via a copper(ii) catalysed aerial oxidation of indole containing benzoins. This journal is

Palladium Catalyzed Carbonylative Coupling for Synthesis of Arylketones and Arylesters Using Chloroform as the Carbon Monoxide Source

We describe a modular, palladium catalyzed synthesis of aryl(hetero)aryl benzophenones and aryl benzoates from aryl(hetero)aryl halides using CHCl3 as the carbonyl source in the presence of KOH. The reaction occurs in tandem through an initial carbonylation to generate an aroyl halide, which undergoes coupling with arylboronic acids, bornonates, and phenols. Direct carbonylative coupling of indoles at the third position has also been accomplished under slightly modified reaction conditions by in situ activation of the C-H bond. Notably, CHCl3 is a convenient and safe alternation of CO gas, provides milder reaction conditions with high functional group tolerance, and gives the products in moderate to good yields.

Synthesis of carbonylated heteroaromatic compounds: Via visible-light-driven intramolecular decarboxylative cyclization of o -alkynylated carboxylic acids

An efficient strategy for the easy access to carbonylated heteroaromatic compounds has been developed via a visible-light-promoted intramolecular decarboxylative cyclization reaction of o-alkynylated carboxylic acids. This method is characterized by its b

Palladium-Catalyzed Carbonylation of Indoles using Aryl Formates as Bifunctional Reagents: A Route to Indol-3-yl Aryl Ketones

A new Pd-catalyzed carbonylation of indoles for the synthesis of indol-3-yl aryl ketones under CO-free conditions was developed. The reaction showed a broad substrate scope with moderate to excellent yields.

Palladium-catalyzed carbonylation of indoles for synthesis of indol-3-yl aryl ketones

A novel palladium-catalyzed carbonylation of indoles with CO and aromatic boronic acids for the synthesis of indol-3-yl aryl ketones was developed. The reaction tolerates a wide range of functional groups and gives a variety of valuable indol-3-yl aryl ketones in high yields under mild conditions. (Chemical Presented).

Copper-promoted decarboxylative direct C3-acylation of N-substituted indoles with α-oxocarboxylic acids

A novel and efficient Cu-promoted decarboxylative direct C3-acylation of N-substituted indoles with α-oxocarboxylic acids for the synthesis of 3-acylindoles was developed. The Royal Society of Chemistry.

Palladium-copper-cocatalyzed intramolecular oxidative coupling: An efficient and atom-economical strategy for the synthesis of 3-acylindoles

A new and efficient catalytic approach to the synthesis of 3-acylindoles under Pd-Cu-cocatalyzed oxidative conditions is demonstrated. tert-Butyl hydroperoxide (TBHP) acts not only as the oxidant, but also as an oxygen source in the approach. The process allows quick and atom-economical assembly of 3-acylindoles from readily available starting materials and tolerates a broad range of functional groups.